Radiologic observation: repair of focal bone erosions after humanized antitumor necrosis factor antibody adalimumab therapy in a patient with rheumatoid arthritis

被引：11

作者：

Ahn, Inhye E. ^{[1
]}

Ju, Ji Hyeon ^{[1
]}

Park, Sung-Hwan ^{[1
]}

Kim, Ho-Youn ^{[1
]}

机构：

[1] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med,Div Rheumatol, Seoul, South Korea

来源：

CLINICAL RHEUMATOLOGY | 2010年 / 29卷 / 02期

关键词：

Adalimumab; Bone resorption; Osteoclasts; Rheumatoid arthritis; Tumor necrosis factor-alpha; JOINT DAMAGE;

D O I：

10.1007/s10067-009-1293-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Erosions of the bone and cartilage are considered as a cardinal feature of rheumatoid arthritis (RA) leading to joint destruction and functional limitations. This report is a radiologic observation of distinguishable bone erosion repair with concomitant increase of radio-opacity of trabecular bones after 15 months of antitumor necrosis factor (TNF) antibody adalimumab therapy in a 26-year-old woman with RA resistant to conventional therapy. Although the introduction of anti-TNF antibodies has contributed to the slowing and arrest of RA progression, destruction itself has been generally acknowledged as an irreversible process with little hope (only 1.8% of erosions) in resolution. Our patient's dramatic structural retrieval is a discrepant, yet notable case pivoting the previous belief on the skeletal restoration capacity of anti-TNF antibody into a circulating cytokine-dependent manner.

引用

页码：211 / 213

页数：3

共 9 条

[1] Erosive progression is minimal, but erosion healing rare, in patients with rheumatoid arthritis treated with adalimumab. A 1 year investigator-initiated follow-up study using high-resolution computed tomography as the primary outcome measure [J].