Rossinones A and B, Biologically Active Meroterpenoids from the Antarctic Ascidian, Aplidium species

被引：50

作者：

Appleton, David R. ^{[1
,2
]}

Chuen, Cheah Shiau ^{[2
]}

Berridge, Michael V. ^{[3
]}

Webb, Victoria L. ^{[4
]}

Copp, Brent R. ^{[1
]}

机构：

[1] Univ Auckland, Dept Chem, Auckland, New Zealand

[2] Univ Malaya, Fac Med, Dept Pharmacol, Ctr Nat Prod Res & Drug Discovery, Kuala Lumpur 50603, Malaysia

[3] Malaghan Inst Med Res, Wellington, New Zealand

[4] Natl Inst Water & Atmospher Res NIMA Ltd, Wellington, New Zealand

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 23期

关键词：

RESPIRATORY BURST; MARINE; METABOLITES; DERIVATIVES; INHIBITORS;

D O I：

10.1021/jo901846j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rossinones A (1) and B (2), biologically active meroterpene derivatives, were isolated from an Antarctic collection of the ascidian Aplidium species and structurally characterized with spectroscopic methods. The absolute configuration of 1 was deduced by using the modified Mosher method. The rossinones exhibit anti-inflammatory, antiviral and antiproliferative activities.

引用

页码：9195 / 9198

页数：4

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