Uremic Pruritus is Associated with Two-Year Cardiovascular Mortality in Long Term Hemodialysis Patients

被引：34
作者：
Weng, Cheng-Hao [1 ,2 ,3 ]
Hu, Ching-Chih [3 ,4 ,5 ]
Yen, Tzung-Hai [1 ,2 ,3 ]
Hsu, Ching-Wei [1 ,2 ,3 ]
Huang, Wen-Hung [1 ,2 ,3 ]
机构：
[1] Chang Gung Mem Hosp, Linkou Med Ctr, Dept Nephrol, 5 Fu Shing St, Taoyuan 333, Taiwan
[2] Chang Gung Mem Hosp, Linkou Med Ctr, Div Clin Toxicol, 5 Fu Shing St, Taoyuan 333, Taiwan
[3] Chang Gung Univ, Coll Med, Taoyuan, Taiwan
[4] Chang Gung Mem Hosp, Dept Hepatogastroenterol, Keelung, Taiwan
[5] Chang Gung Mem Hosp, Liver Res Unit, Keelung, Taiwan
来源：
KIDNEY & BLOOD PRESSURE RESEARCH | 2018年 / 43卷 / 03期
关键词：
Uremic pruritus; Cardiovascular; Mortality; Hemodialysis; LEFT-VENTRICULAR HYPERTROPHY; HEPATITIS-C; MAINTENANCE HEMODIALYSIS; ARTERIOVENOUS-FISTULA; NATRIURETIC PEPTIDE; DIALYSIS OUTCOMES; PRACTICE PATTERNS; DOUBLE-BLIND; RENAL ITCH; INFECTION;
D O I：
10.1159/000490689
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Background/Aims: Uremic pruritus (UP) is an unpleasant complication in patients undergoing maintenance dialysis. Cardiovascular and infection related deaths are the major causes of mortality in patients undergoing dialysis. Studies on the correlation between cardiovascular or infection related mortality and UP are limited. Methods: We analyze 866 maintenance hemodialysis (MHD) patients in our hemodialysis centers. Clinical parameters and 24-month cardiovascular and infection-related mortality are recorded. Results: The associations between all-cause, cardiovascular and infection related mortality with clinical data including UP are analyzed. Multivariate Cox regression demonstrated that UP is a significantly predictor for 24-month cardiovascular mortality in the MHD patients (Hazard ratio: 3.164; 95% confidence interval, 1.743-5.744; p < 0.001). Conclusion: Uremic pruritus is one of the predictor of 24-month cardiovascular mortality in MHD patients. (C) 2018 The Author(s) Published by S. Karger AG, Basel
引用
收藏
页码：1000 / 1009
页数：10
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