Stromal cell-derived factor-1/CXC chemokine receptor 4 axis in injury repair and renal transplantation

被引：14
作者：
Sun, Zejia [1 ]
Li, Xin [1 ]
Zheng, Xiang [1 ]
Cao, Peng [1 ]
Yu, Baozhong [1 ]
Wang, Wei [1 ]
机构：
[1] Capital Med Univ, Beijing Chaoyang Hosp, Dept Urol, Inst Urol, 7th Floor,Bldg B,8 Workers Stadium South Rd, Beijing 100020, Peoples R China
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2019年 / 47卷 / 11期
基金：
中国国家自然科学基金;
关键词：
SDF-1; CXCR4; stem cell; injury repair; renal transplantation; MESENCHYMAL STEM-CELLS; MOBILIZING AGENTS RESULT; SHORT-TERM TREATMENT; BONE-MARROW-CELLS; TISSUE-REPAIR; EPITHELIAL-CELLS; PROGENITOR CELLS; FACTOR-I; G-CSF; KIDNEY;
D O I：
10.1177/0300060519876138
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Stem cell therapy has shown promise in treating a variety of pathologies, such as myocardial infarction, ischaemic stroke and organ transplantation. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) axis plays a key role in stem cell mobilization. This review describes the important role of SDF-1 in tissue injury and how it works in tissue revascularization and regeneration via CXCR4. Furthermore, factors influencing the SDF-1/CXCR4 axis and its clinical potential in ischaemia reperfusion injury, such as renal transplantation, are discussed. Exploring signalling pathways of the SDF-1/CXCR4 axis will contribute to the development of stem cell therapy so that more clinical problems can be solved. Controlling directional homing of stem cells through the SDF-1/CXCR4 axis is key to improving the efficacy of stem cell therapy for tissue injury. CXCR4 antagonists may also be effective in increasing circulating levels of adult stem cells, thereby exerting beneficial effects on damaged or inflamed tissues in diseases that are currently not treated by standard approaches.
引用
收藏
页码：5426 / 5440
页数：15
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