MAGE-A family is involved in gastric cancer progression and indicates poor prognosis of gastric cancer patients

被引:22
作者
Lian, Yishui [1 ]
Sang, Meixiang [1 ,2 ]
Gu, Lina [1 ]
Liu, Fei [1 ,2 ]
Yin, Danjing [1 ]
Liu, Shina [1 ,2 ]
Huang, Weina [1 ,2 ]
Wu, Yanyun [1 ,2 ]
Shan, Baoen [1 ,2 ]
机构
[1] Hebei Med Univ, Hosp 4, Res Ctr, Shijiazhuang 050017, Hebei, Peoples R China
[2] Hebei Med Univ, Hosp 4, Tumor Res Inst, Shijiazhuang 050017, Hebei, Peoples R China
关键词
Gastric cancer; Intraepithelial neoplasia; MAGE-A; Prognosis; MELANOMA ANTIGEN; TUMOR-CELLS; EXPRESSION; GENES; IDENTIFICATION;
D O I
10.1016/j.prp.2017.05.007
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Background: As the best characterized CTA family members, melanoma-associated antigens (MAGE) have been reported to express in various malignant tumors. However, the expression pattern of MAGE-A family in gastric cancer (GC) specimens and their prognostic and therapeutic significance for GC patients is still unclear. Materials and methods: Tissue microarray based immunohistochemistry analysis was used to examine the expression of MAGE-A family members (including MAGE-Al, -A2, -A3, -A4, -A6, -A10, and -A12).in 86 cases of GC specimens, 20 cases of the corresponding adjacent normal gastric specimens, and 9 cases of intraepithelial neoplasia specimens. The association between MAGE-A expression and the clinicopathological parameters as well as the 5-year overall survival of GC patients was analyzed. Results: 54.7% of GC specimens showed positive MAGE-A expression. In the adjacent normal gastric specimens, MAGE-A was not expressed in the normal surface mucous cells, but expressed in some normal fundic glands. In addition, MAGE-A expression was also detected in intraepithelial neoplasia specimens. In GC specimens, MAGE-A expression was associated with lymph node metastasis, poor differentiation, and high clinical TNM stage. MAGE-A expression was also correlated with the poor 5-year overall survival of GC patients. However, MAGE-A expression is not an independent prognostic factor for GC patients. Conclusions: MAGE-A family may be involved in the gastric cancer progression, and their expression could be considered to improve the prognostic evaluation for GC patients. (C) 2017 Elsevier GmbH. All rights reserved.
引用
收藏
页码:943 / 948
页数:6
相关论文
共 30 条
[21]   MAGE A3 antigen-specific cancer immunotherapeutic [J].
Peled, Nir ;
Oton, Ana B. ;
Hirsch, Fred R. ;
Bunn, Paul .
IMMUNOTHERAPY, 2009, 1 (01) :19-25
[22]   Safety and Immunogenicity of MAGE-A3 Cancer Immunotherapeutic with or without Adjuvant Chemotherapy in Patients with Resected Stage IB to III MAGE-A3-Positive Non-Small-Cell Lung Cancer [J].
Pujol, Jean-Louis ;
Vansteenkiste, Johan F. ;
De Pas, Tommaso Martino ;
Atanackovic, Djordje ;
Reck, Martin ;
Thomeer, Michiel ;
Douillard, Jean-Yves ;
Fasola, Gianpiero ;
Potter, Vanessa ;
Taylor, Paul ;
Bosquee, Lionel ;
Scheubel, Robert ;
Jarnjak, Silvija ;
Debois, Muriel ;
Alves, Pedro de Sousa ;
Louahed, Jamila ;
Brichard, Vincent G. ;
Lehmann, Frederic F. .
JOURNAL OF THORACIC ONCOLOGY, 2015, 10 (10) :1458-1467
[23]   THE MELANOMA ANTIGEN GENE (MAGE) FAMILY IS CLUSTERED IN THE CHROMOSOMAL BAND XQ28 [J].
ROGNER, UC ;
WILKE, K ;
STECK, E ;
KORN, B ;
POUSTKA, A .
GENOMICS, 1995, 29 (03) :725-731
[24]   Multiple MAGE-A genes as surveillance marker for the detection of circulating tumor cells in patients with ovarian cancer [J].
Sang, Meixiang ;
Wu, Xiaohua ;
Fan, Xiaojie ;
Sang, Meijie ;
Zhou, Xinliang ;
Zhou, Nan .
BIOMARKERS, 2014, 19 (01) :34-42
[25]   MAGE-A family: Attractive targets for cancer immunotherapy [J].
Sang, Meixiang ;
Lian, Yishui ;
Zhou, Xinliang ;
Shan, Baoen .
VACCINE, 2011, 29 (47) :8496-8500
[26]   Melanoma-associated antigen genes - An update [J].
Sang, Meixiang ;
Wang, Lifang ;
Ding, Chunyan ;
Zhou, Xinliang ;
Wang, Bin ;
Wang, Ling ;
Lian, Yishui ;
Shan, Baoen .
CANCER LETTERS, 2011, 302 (02) :85-90
[27]   Promoter methylation controls the expression of MAGE2, 3 and 4 genes in human cutaneous melanoma [J].
Sigalotti, L ;
Coral, S ;
Nardi, G ;
Spessotto, A ;
Cortini, E ;
Cattarossi, I ;
Colizzi, F ;
Altomonte, M ;
Maio, M .
JOURNAL OF IMMUNOTHERAPY, 2002, 25 (01) :16-26
[28]   Screening of gastric cancer in Asia [J].
Sugano, Kentaro .
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2015, 29 (06) :895-905
[29]   A GENE ENCODING AN ANTIGEN RECOGNIZED BY CYTOLYTIC LYMPHOCYTES-T ON A HUMAN-MELANOMA [J].
VANDERBRUGGEN, P ;
TRAVERSARI, C ;
CHOMEZ, P ;
LURQUIN, C ;
DEPLAEN, E ;
VANDENEYNDE, B ;
KNUTH, A ;
BOON, T .
SCIENCE, 1991, 254 (5038) :1643-1647
[30]   Adjuvant MAGE-A3 Immunotherapy in Resected Non-Small-Cell Lung Cancer: Phase II Randomized Study Results [J].
Vansteenkiste, Johan ;
Zielinski, Marcin ;
Linder, Albert ;
Dahabreh, Jubrail ;
Gonzalez, Emilio E. ;
Malinowski, Wojciech ;
Lopez-Brea, Marta ;
Vanakesa, Tonu ;
Jassem, Jacek ;
Kalofonos, Haralabos ;
Perdeus, Jakub ;
Bonnet, Reiner ;
Basko, Jazeps ;
Janilionis, Richard ;
Passlick, Bernward ;
Treasure, Tom ;
Gillet, Marc ;
Lehmann, Frederic F. ;
Brichard, Vincent G. .
JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (19) :2396-+