The roles of mesenchymal stem cells (MSCs) therapy in ischemic heart diseases

被引：49

作者：

Wang, Xiao-Jun ^{[1
]}

Li, Qing-Ping ^{[1
]}

机构：

[1] Nanjing Med Univ, Dept Pharmacol, Nanjing 210029, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 359卷 / 02期

关键词：

MSCs; ischemic heart diseases; transplantation;

D O I：

10.1016/j.bbrc.2007.05.112

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Growing cell-based myocardial therapies which could lead to successful myocardial repair attracts medical interest. Even more intriguing is the observation that MSCs appears to be a more potent material among kinds of stem cells for the transplantation, the mechanism for this benefit remains unclear. However, the therapeutic contribution of MSCs to myocardial repair can be caused by multiple factors including: direct differentiation into cardiac tissue including cardiomyocytes, smooth muscle cell, and vascular endothelial cells; secreting a variety of cytokines and growth factors that have paracrine activities; spontaneous cell fusion; and stimulating enclogenous repair. In addition, MSCs possess local immunosuppressive properties, and MSCs mobilization is widely used clinically for transplantation. We will discusses the potential mechanisms of MSCs repair for ischemic heart diseases. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：189 / 193

页数：5

共 58 条

[1] Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes [J].

Alvarez-Dolado, M ;

Pardal, R ;

Garcia-Vardugo, JM ;

Fike, JR ;

Lee, HO ;

Pfeffer, K ;

Lois, C ;

Morrison, SJ ;

Alvarez-Buylla, A .

NATURE, 2003, 425 (6961) :968-973

[2] Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway [J].

Augello, A ;

Tasso, R ;

Negrini, SM ;

Amateis, A ;

Indiveri, F ;

Cancedda, R ;

Pennesi, G .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (05) :1482-1490

[3] Adult cardiac stem cells are multipotent and support myocardial regeneration [J].

Beltrami, AP ;

Barlucchi, L ;

Torella, D ;

Baker, M ;

Limana, F ;

Chimenti, S ;

Kasahara, H ;

Rota, M ;

Musso, E ;

Urbanek, K ;

Leri, A ;

Kajstura, J ;

Nadal-Ginard, B ;

Anversa, P .

CELL, 2003, 114 (06) :763-776

[4] Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness [J].

Beyth, S ;

Borovsky, Z ;

Mevorach, D ;

Liebergall, M ;

Gazit, Z ;

Aslan, H ;

Galun, E ;

Rachmilewitz, J .

BLOOD, 2005, 105 (05) :2214-2219

[5] Nerve sprouting and sudden cardiac death [J].

Cao, JM ;

Chen, LS ;

KenKnight, BH ;

Ohara, T ;

Lee, MH ;

Tsai, J ;

Lai, WW ;

Karagueuzian, HS ;

Wolf, PL ;

Fishbein, MC ;

Chen, PS .

CIRCULATION RESEARCH, 2000, 86 (07) :816-821

[6] Mesenchymal stem cells as trophic mediators [J].

Caplan, Arnold I. ;

Dennis, James E. .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2006, 98 (05) :1076-1084

[7] Human mesenchymal stem cells modulate B-cell functions [J].

Corcione, A ;

Benvenuto, F ;

Ferretti, E ;

Giunti, D ;

Cappiello, V ;

Cazzanti, F ;

Risso, M ;

Gualandi, F ;

Mancardi, GL ;

Pistoia, V ;

Uccelli, A .

BLOOD, 2006, 107 (01) :367-372

[8] Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model [J].

Davani, S ;

Marandin, A ;

Mersin, N ;

Royer, B ;

Kantelip, B ;

Hervé, P ;

Etievent, JP ;

Kantelip, JP .

CIRCULATION, 2003, 108 (10) :253-258

[9] Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli [J].

Di Nicola, M ;

Carlo-Stella, C ;

Magni, M ;

Milanesi, M ;

Longoni, PD ;

Matteucci, P ;

Grisanti, S ;

Gianni, AM .

BLOOD, 2002, 99 (10) :3838-3843

[10] Growth hormone and the insulin-like growth factor system in myogenesis [J].

Florini, JR ;

Ewton, DZ ;

Coolican, SA .

ENDOCRINE REVIEWS, 1996, 17 (05) :481-517

← 1 2 3 4 5 6 →