Increased prolyl endopeptidase activity in human neoplasia

被引：33

作者：

Larrinaga, Gorka ^{[1
]}

Perez, Itxaro ^{[1
]}

Blanco, Lorena ^{[1
]}

Lopez, Jose I. ^{[2
]}

Andres, Leire ^{[2
]}

Etxezarraga, Carmen ^{[3
]}

Santaolalla, Francisco ^{[4
,5
]}

Zabala, Aitor ^{[5
]}

Varona, Adolfo ^{[1
]}

Irazusta, Jon ^{[1
,6
]}

机构：

[1] Sch Med & Dent, Dept Physiol, Leioa, Bizkaia, Spain

[2] Univ Hosp Cruces, Dept Anat Pathol, Baracaldo, Bizkaia, Spain

[3] Univ Hosp Basurto, Dept Anat Pathol, Bilbao, Bizkaia, Spain

[4] Sch Med & Dent, Dept Otolaryngol, Leioa, Bizkaia, Spain

[5] Univ Basque Country, Hosp Basurto, Dept Otolaryngol, Bilbao 48080, Bizkaia, Spain

[6] CIBERSAM, Madrid, Spain

来源：

REGULATORY PEPTIDES | 2010年 / 163卷 / 1-3期

关键词：

Prolyl endopeptidase; Prolyl oligopeptidase; PEP; Cancer; Tumor markers; Bioactive peptides; FIBROBLAST ACTIVATION PROTEIN; MATRIX METALLOPROTEINASES; SUBCELLULAR-LOCALIZATION; AMINOPEPTIDASE ACTIVITY; OLIGOPEPTIDASE; RAT; EXPRESSION; MEMBRANE; ENZYME; ANGIOGENESIS;

D O I：

10.1016/j.regpep.2010.03.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Prolyl endopeptidase (EC 3.4 21.26) (PEP) is a serine peptidase that converts several biologically active peptides This enzyme has been linked to several neurological, digestive, cardiovascular and infectous disorders However, little is known about its involvement in neoplastic processes This study analyzes fluorimetrically cytosolic and membrane-bound PEP activity in a large series (n = 122) of normal and neoplastic tissues from the kidney, colon, oral cavity, larynx, thyroid gland and testis Cytosolic PEP activity significantly increased in clear cell renal cell carcinoma, urothelial carcinoma of the renal pelvis and head and neck squamous cell carcinoma Both cytosolic and membrane-bound PEP activity were also increased in colorectal adenomatous polyps. These data suggest the Involvement of PEP in some mechanisms that underlie neoplastic processes (C) 2010 Elsevier B V All rights reserved

引用

页码：102 / 106

页数：5

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