Lepidepyrone, a new γ-pyrone derivative, from Neolentinus lepideus, inhibits hyaluronidase

被引：7

作者：

Hosoe, Tomoo

Sakai, Hideo

Ichikawa, Makoto

Itabashi, Takeshi

Ishizaki, Takayuki

Kawai, Ken-ichi

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan

[2] Tamagawa Univ, Res Inst, Tokyo 1948610, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2007年 / 60卷 / 06期

关键词：

Neolentinus lepideus; gamma-pyrone derivative; lepidepyrone; hyaluronidase inhibitor;

D O I：

10.1038/ja.2007.53

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In the course of screening for hyaluronidase (HAase) inhibitory agents, a new gamma-pyrone derivative, lepidepyrone, C8H10O5, was isolated from the cultured mycelium of the mushroom Neolentinus lepideus TMC-1102 as a major HAase inhibitory compound (IC50 3.3 mM). The structure of lepidepyrone was established on the basis of spectroscopic investigation.

引用

页码：388 / 390

页数：3

共 7 条

[1] ALEXANDER B, 2004, J BIOL CHEM, V44, P45990
[2] Structure of Sch 419560, a novel α-pyrone antibiotic produced by Pseudomonas fluorescens
Chu, M
Mierzwa, R
Xu, L
He, L
Terracciano, J
Patel, M
Zhao, W
Black, TA
Chan, TM
[J]. JOURNAL OF ANTIBIOTICS, 2002, 55 (02) : 215 - 218
[3] Inhibitory effects of microalgae on the activation of hyaluronidase
Fujitani, N
Sakaki, S
Yamaguchi, Y
Takenaka, H
[J]. JOURNAL OF APPLIED PHYCOLOGY, 2001, 13 (06) : 489 - 492
[4] Kobayashi M, 2004, INT J MOL MED, V14, P879
[5] HYALURONAN
LAURENT, TC
FRASER, JRE
[J]. FASEB JOURNAL, 1992, 6 (07) : 2397 - 2404
[6] Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases
Spickenreither, Martin
Braun, Stephan
Bernhardt, Guenther
Dove, Stefan
Buschauer, Armin
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (20) : 5313 - 5316
[7] PRODUCTION OF METHYLATED PHENOLIC ACIDS BY SPECIES OF LENTINUS (BASIDIOMYCETES)
WAT, CK
TOWERS, GHN
[J]. PHYTOCHEMISTRY, 1977, 16 (02) : 290 - 291

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