The effects of nicotine, denicotinized tobacco, and nicotine-containing tobacco on cigarette craving, withdrawal, and self-administration in male and female smokers

被引:75
作者
Barrett, Sean P. [1 ]
机构
[1] Dalhousie Univ, Dept Psychol, Halifax, NS B3H 4J1, Canada
来源
BEHAVIOURAL PHARMACOLOGY | 2010年 / 21卷 / 02期
基金
加拿大自然科学与工程研究理事会;
关键词
craving; human; nicotine; nicotine replacement therapy; progressive ratio schedule; tobacco; GENDER-DIFFERENCES; SMOKING CESSATION; INSTRUCTIONS; ACETALDEHYDE; ABSTINENCE; PATCHES;
D O I
10.1097/FBP.0b013e328337be68
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The effects of the acute administration of nicotine [through nicotine inhalers (NI) and placebo inhalers (PI)], nicotine-containing tobacco (NT), and denicotinized tobacco (DT), on smokers' subjective responses and motivation to smoke were examined in 22 smokers (12 male, 10 female; 11 low dependent, 11 high dependent). During four randomized blinded sessions, participants self-administered NI, PI, NT, or DT, and assessed their effects using Visual Analogue Scales and the Brief Questionnaire of Smoking Urges. They could then self-administer their preferred brand of cigarettes using a progressive ratio task. NT and DT were each associated with increased satisfaction and relaxation as well as decreased craving relative to the inhalers and NT increased ratings of stimulation relative to each of the other products. Both NT and DT delayed the onset of preferred tobacco self-administration relative to NI and PI but only NT reduced the total amount self-administered. Sex differences were evident in the effects of DT on withdrawal-related cravings with women experiencing greater DT-induced craving relief than men. Findings suggest that DT is effective in acutely reducing many smoking abstinence symptoms, especially in women, but a combination of nicotine and non-nicotine tobacco ingredients may be necessary to suppress smoking behavior. Behavioural Pharmacology 21:144-152 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码:144 / 152
页数:9
相关论文
共 58 条
[1]  
[Anonymous], REP GLOB TOB EP 2008
[2]  
[Anonymous], DHHS PUBLICATION
[3]   SWITCHING TO ULTRALOW NICOTINE CIGARETTES - EFFECTS OF DIFFERENT TAR YIELDS AND BLOCKING OF OLFACTORY CUES [J].
BALDINGER, B ;
HASENFRATZ, M ;
BATTIG, K .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1995, 50 (02) :233-239
[4]   The role of dopamine in alcohol self-administration in humans: Individual differences [J].
Barrett, Sean P. ;
Pihl, Robert O. ;
Benkelfat, Chawki ;
Brunelle, Caroline ;
Young, Simon N. ;
Leyton, Marco .
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2008, 18 (06) :439-447
[5]   Nicotine increases alcohol self-administration in non-dependent male smokers [J].
Barrett, SP ;
Tichauer, M ;
Leyton, M ;
Pihl, RO .
DRUG AND ALCOHOL DEPENDENCE, 2006, 81 (02) :197-204
[6]   A randomized trial of nicotine replacement therapy in combination with reduced-nicotine cigarettes for smoking cessation [J].
Becker, Karen M. ;
Rose, Jed E. ;
Albino, Anthony P. .
NICOTINE & TOBACCO RESEARCH, 2008, 10 (07) :1139-1148
[7]  
BOND AJ, 1972, BRIT J PHARMACOL, V44, pP343
[8]  
Brauer L H, 2001, Nicotine Tob Res, V3, P101
[9]   Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette [J].
Brody, Arthur L. ;
Mandelkern, Mark A. ;
Costello, Matthew R. ;
Abrams, Anna L. ;
Scheibal, David ;
Farahi, Judah ;
London, Edythe D. ;
Olmstead, Richard E. ;
Rose, Jed E. ;
Mukhin, Alexey G. .
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2009, 12 (03) :305-316
[10]   Distress tolerance and early smoking lapse [J].
Brown, RA ;
Lejuez, CW ;
Kahler, CW ;
Strong, DR ;
Zvolensky, MJ .
CLINICAL PSYCHOLOGY REVIEW, 2005, 25 (06) :713-733