Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment

被引：63
作者：
Ciudin, Andreea [1 ,2 ]
Espinosa, Ana [3 ]
Simo-Servat, Olga [1 ,2 ]
Ruiz, Agustin [3 ]
Alegret, Montserrat [3 ]
Hernandez, Cristina [1 ,2 ]
Boada, Merce [3 ]
Simo, Rafael [1 ,2 ]
机构：
[1] Univ Autonoma Barcelona VHIR UAB, Inst Recerca Vall dHebron, Barcelona, Spain
[2] CIBER Diabet & Enfermedades Metabol Asociadas, Inst Salud Carlos 3, Madrid, Spain
[3] Fundacio ACE, Barcelona Alzheimer Treatment & Res Ctr, Barcelona, Spain
来源：
JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2017年 / 31卷 / 08期
关键词：
FOLLOW-UP; ALZHEIMERS-DISEASE; PEOPLE; MELLITUS;
D O I：
10.1016/j.jdiacomp.2017.04.018
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aims: To explore whether type 2 diabetes (T2D) is a risk factor for dementia conversion in patients with mild cognitive impairment (MCI). Methods: A longitudinal nested case-control study in which 101 T2D patients and 101 non-diabetic patients with MCI matched by age and gender were included. Results: The dementia conversion rate was 57.4% in T2D patients vs. 42.6% in non-diabetic subjects (p = 0.02).T2D and APOE epsilon 4 allele were independent risk factors for developing dementia. Conclusion: T2D is an independent risk factor for dementia conversion in MCI patients. This finding has significant clinical implications. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：1272 / 1274
页数：3
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