Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment

被引：63
作者：
Ciudin, Andreea [1 ,2 ]
Espinosa, Ana [3 ]
Simo-Servat, Olga [1 ,2 ]
Ruiz, Agustin [3 ]
Alegret, Montserrat [3 ]
Hernandez, Cristina [1 ,2 ]
Boada, Merce [3 ]
Simo, Rafael [1 ,2 ]
机构：
[1] Univ Autonoma Barcelona VHIR UAB, Inst Recerca Vall dHebron, Barcelona, Spain
[2] CIBER Diabet & Enfermedades Metabol Asociadas, Inst Salud Carlos 3, Madrid, Spain
[3] Fundacio ACE, Barcelona Alzheimer Treatment & Res Ctr, Barcelona, Spain
来源：
JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2017年 / 31卷 / 08期
关键词：
FOLLOW-UP; ALZHEIMERS-DISEASE; PEOPLE; MELLITUS;
D O I：
10.1016/j.jdiacomp.2017.04.018
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aims: To explore whether type 2 diabetes (T2D) is a risk factor for dementia conversion in patients with mild cognitive impairment (MCI). Methods: A longitudinal nested case-control study in which 101 T2D patients and 101 non-diabetic patients with MCI matched by age and gender were included. Results: The dementia conversion rate was 57.4% in T2D patients vs. 42.6% in non-diabetic subjects (p = 0.02).T2D and APOE epsilon 4 allele were independent risk factors for developing dementia. Conclusion: T2D is an independent risk factor for dementia conversion in MCI patients. This finding has significant clinical implications. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：1272 / 1274
页数：3
相关论文
共 50 条
  • [41] Factors Associated With Mild Cognitive Impairment in Patients With Type 2 Diabetes: A Cohort Study
    Tlemcani, Fatima Zahra Rhmari
    Elamari, Saloua
    Motaib, Imane
    Laidi, Soukaina
    Alidrissi, Najib
    Ahid, Samir
    Chadli, Asmaa
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (08)
  • [42] White Matter Atrophy in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment
    Li, Chang
    Jin, Rongbing
    Liu, Kaijun
    Li, Yang
    Zuo, Zhiwei
    Tong, Haipeng
    Zhang, Jingna
    Zhang, Junfeng
    Guo, Yu
    Lai, Yuqi
    Sun, Jinju
    Wang, Jian
    Xiong, Kunlin
    Chen, Xiao
    FRONTIERS IN NEUROSCIENCE, 2021, 14
  • [43] Assessment of comorbid mild cognitive impairment and depression in patients with type 2 diabetes mellitus
    Abd Elaaty, Talaat A.
    Ismail, Azza A.
    Sheshtawy, Hesham A.
    Sultan, Eman A.
    Ebrahim, Mohamed G.
    DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS, 2019, 13 (03) : 1759 - 1764
  • [44] An Update on Type 2 Diabetes Mellitus as a Risk Factor for Dementia
    Li, Wei
    Huang, Edgar
    JOURNAL OF ALZHEIMERS DISEASE, 2016, 53 (02) : 393 - 402
  • [45] Aggravated Cognitive and Brain Functional Impairment in Mild Cognitive Impairment Patients with Type 2 Diabetes: A Resting-State Functional MRI Study
    Zhou, Xiaoqing
    Zhang, Junying
    Chen, Yaojing
    Ma, Tao
    Wang, Yunxia
    Wang, Jun
    Zhang, Zhanjun
    JOURNAL OF ALZHEIMERS DISEASE, 2014, 41 (03) : 925 - 935
  • [46] Predictors of Conversion to Dementia in Patients With Mild Cognitive Impairment: The Role of Low Body Temperature
    Alagiakrishnan, Kannayiram
    Dhami, Prabhpaul
    Senthilselvan, Ambikaipakan
    JOURNAL OF CLINICAL MEDICINE RESEARCH-CANADA, 2023, 15 (04): : 216 - 224
  • [47] Type 2 Diabetes and 10-Year Risk of Dementia and Cognitive Impairment Among Older Mexican Americans
    Mayeda, Elizabeth R.
    Haan, Mary N.
    Kanaya, Alka M.
    Yaffe, Kristine
    Neuhaus, John
    DIABETES CARE, 2013, 36 (09) : 2600 - 2606
  • [48] Risk of Suicide Attempt in Patients With Recent Diagnosis of Mild Cognitive Impairment or Dementia
    Gunak, Mia Maria
    Barnes, Deborah E.
    Yaffe, Kristine
    Li, Yixia
    Byers, Amy L.
    JAMA PSYCHIATRY, 2021, 78 (06) : 659 - 666
  • [49] Memory Concerns, Memory Performance and Risk of Dementia in Patients with Mild Cognitive Impairment
    Wolfsgruber, Steffen
    Wagner, Michael
    Schmidtke, Klaus
    Froelich, Lutz
    Kurz, Alexander
    Schulz, Stefanie
    Hampel, Harald
    Heuser, Isabella
    Peters, Oliver
    Reischies, Friedel M.
    Jahn, Holger
    Luckhaus, Christian
    Huell, Michael
    Gertz, Hermann-Josef
    Schroeder, Johannes
    Pantel, Johannes
    Rienhoff, Otto
    Ruether, Eckart
    Henn, Fritz
    Wiltfang, Jens
    Maier, Wolfgang
    Kornhuber, Johannes
    Jessen, Frank
    PLOS ONE, 2014, 9 (07):
  • [50] Lipoprotein-associated Phospholipase A2 Is Associated with Risk of Mild Cognitive Impairment in Chinese Patients with Type 2 Diabetes
    Cai, Rongrong
    Huang, Rong
    Han, Jing
    Sun, Haixia
    Sun, Jie
    Xia, Wenqing
    Tian, Sai
    Dong, Xue
    Shen, Yanjue
    Wang, Shaohua
    SCIENTIFIC REPORTS, 2017, 7
12345