Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment

被引：63
作者：
Ciudin, Andreea [1 ,2 ]
Espinosa, Ana [3 ]
Simo-Servat, Olga [1 ,2 ]
Ruiz, Agustin [3 ]
Alegret, Montserrat [3 ]
Hernandez, Cristina [1 ,2 ]
Boada, Merce [3 ]
Simo, Rafael [1 ,2 ]
机构：
[1] Univ Autonoma Barcelona VHIR UAB, Inst Recerca Vall dHebron, Barcelona, Spain
[2] CIBER Diabet & Enfermedades Metabol Asociadas, Inst Salud Carlos 3, Madrid, Spain
[3] Fundacio ACE, Barcelona Alzheimer Treatment & Res Ctr, Barcelona, Spain
来源：
JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2017年 / 31卷 / 08期
关键词：
FOLLOW-UP; ALZHEIMERS-DISEASE; PEOPLE; MELLITUS;
D O I：
10.1016/j.jdiacomp.2017.04.018
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aims: To explore whether type 2 diabetes (T2D) is a risk factor for dementia conversion in patients with mild cognitive impairment (MCI). Methods: A longitudinal nested case-control study in which 101 T2D patients and 101 non-diabetic patients with MCI matched by age and gender were included. Results: The dementia conversion rate was 57.4% in T2D patients vs. 42.6% in non-diabetic subjects (p = 0.02).T2D and APOE epsilon 4 allele were independent risk factors for developing dementia. Conclusion: T2D is an independent risk factor for dementia conversion in MCI patients. This finding has significant clinical implications. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：1272 / 1274
页数：3
相关论文
共 50 条
  • [31] Subjective Memory Complaints and Conversion to Dementia in Patients with Subjective Cognitive Decline and Patients with Mild Cognitive Impairment
    Lehrner, Johann
    Bodendorfer, Bettina
    Lamm, Claus
    Moser, Doris
    Dal-Bianco, Peter
    Auff, Eduard
    Pusswald, Gisela
    ZEITSCHRIFT FUR NEUROPSYCHOLOGIE, 2016, 27 (02) : 85 - 93
  • [32] Triglyceride Glucose Index is Related with the Risk of Mild Cognitive Impairment in Type 2 Diabetes
    Tong, Xue-Wei
    Zhang, Yi-Tong
    Yu, Zi-Wei
    Pu, Sheng-Dan
    Li, Xin
    Xu, Yu-Xin
    Shan, Yong-Yan
    Gao, Xin-Yuan
    DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2022, 15 : 3577 - 3587
  • [33] Taxifolin for Cognitive Preservation in Patients with Mild Cognitive Impairment or Mild Dementia
    Hattori, Yorito
    Saito, Satoshi
    Nakaoku, Yuriko
    Ogata, Soshiro
    Hattori, Masashi
    Nakatsuji, Mio
    Nishimura, Kunihiro
    Ihara, Masafumi
    JOURNAL OF ALZHEIMERS DISEASE, 2023, 93 (02) : 743 - 754
  • [34] Accelerated Progression From Mild Cognitive Impairment to Dementia in People With Diabetes
    Xu, Weili
    Caracciolo, Barbara
    Wang, Hui-Xin
    Winblad, Bengt
    Backman, Lars
    Qiu, Chengxuan
    Fratiglioni, Laura
    DIABETES, 2010, 59 (11) : 2928 - 2935
  • [35] Development and validation of a risk prediction model for mild cognitive impairment in elderly patients with type 2 diabetes mellitus
    Yu, Qian
    Jiang, Xing
    Yan, Jiarong
    Yu, Hongyu
    GERIATRIC NURSING, 2024, 58 : 119 - 126
  • [36] Neuropsychiatric symptoms and faster progression of cognitive impairments as predictors of risk of conversion of mild cognitive impairment to dementia
    Bidzan, Mariola
    Bidzan, Leszek
    Bidzan-Bluma, Ilona
    ARCHIVES OF MEDICAL SCIENCE, 2017, 13 (05) : 1168 - 1177
  • [37] Orthostatic Hypotension Promotes the Progression From Mild Cognitive Impairment to Dementia in Type 2 Diabetes Mellitus
    Xiong, Qiao
    Li, Fang
    Chi, Haiyan
    Yang, Yachao
    Li, Mengfan
    Liu, Yingxiao
    Zhang, Yupan
    Leng, Bing
    Qi, Xiaoxiao
    Sun, Hairong
    Li, Zhenguang
    Zhang, Jinbiao
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2024, 109 (06) : 1454 - 1463
  • [38] Are depressive symptoms in mild cognitive impairment predictive of conversion to dementia?
    De Roeck, Ellen
    Ponjaert-Kristoffersen, Ingrid
    Bosmans, Marc
    De Deyn, Peter Paul
    Engelborghs, Sebastiaan
    Dierckx, Eva
    INTERNATIONAL PSYCHOGERIATRICS, 2016, 28 (06) : 921 - 928
  • [39] Incidence of Mild Cognitive Impairment, Conversion to Probable Dementia, and Mortality
    Zhang, Yun
    Natale, Ginny
    Clouston, Sean
    AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS, 2021, 36
  • [40] Conversion from subtypes of mild cognitive impairment to Alzheimer dementia
    Fischer, P.
    Jungwirth, S.
    Zehetmayer, S.
    Weissgram, S.
    Hoenigschnabl, S.
    Gelpi, E.
    Krampla, W.
    Tragl, K. H.
    NEUROLOGY, 2007, 68 (04) : 288 - 291
12345