Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment

被引：69

作者：

Ciudin, Andreea ^{[1
,2
]}

Espinosa, Ana ^{[3
]}

Simo-Servat, Olga ^{[1
,2
]}

Ruiz, Agustin ^{[3
]}

Alegret, Montserrat ^{[3
]}

Hernandez, Cristina ^{[1
,2
]}

Boada, Merce ^{[3
]}

Simo, Rafael ^{[1
,2
]}

机构：

[1] Univ Autonoma Barcelona VHIR UAB, Inst Recerca Vall dHebron, Barcelona, Spain

[2] CIBER Diabet & Enfermedades Metabol Asociadas, Inst Salud Carlos 3, Madrid, Spain

[3] Fundacio ACE, Barcelona Alzheimer Treatment & Res Ctr, Barcelona, Spain

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2017年 / 31卷 / 08期

关键词：

FOLLOW-UP; ALZHEIMERS-DISEASE; PEOPLE; MELLITUS;

D O I：

10.1016/j.jdiacomp.2017.04.018

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: To explore whether type 2 diabetes (T2D) is a risk factor for dementia conversion in patients with mild cognitive impairment (MCI). Methods: A longitudinal nested case-control study in which 101 T2D patients and 101 non-diabetic patients with MCI matched by age and gender were included. Results: The dementia conversion rate was 57.4% in T2D patients vs. 42.6% in non-diabetic subjects (p = 0.02).T2D and APOE epsilon 4 allele were independent risk factors for developing dementia. Conclusion: T2D is an independent risk factor for dementia conversion in MCI patients. This finding has significant clinical implications. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：1272 / 1274

页数：3

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