Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment

被引：64
|
作者：
Ciudin, Andreea [1 ,2 ]
Espinosa, Ana [3 ]
Simo-Servat, Olga [1 ,2 ]
Ruiz, Agustin [3 ]
Alegret, Montserrat [3 ]
Hernandez, Cristina [1 ,2 ]
Boada, Merce [3 ]
Simo, Rafael [1 ,2 ]
机构：
[1] Univ Autonoma Barcelona VHIR UAB, Inst Recerca Vall dHebron, Barcelona, Spain
[2] CIBER Diabet & Enfermedades Metabol Asociadas, Inst Salud Carlos 3, Madrid, Spain
[3] Fundacio ACE, Barcelona Alzheimer Treatment & Res Ctr, Barcelona, Spain
来源：
JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2017年 / 31卷 / 08期
关键词：
FOLLOW-UP; ALZHEIMERS-DISEASE; PEOPLE; MELLITUS;
D O I：
10.1016/j.jdiacomp.2017.04.018
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aims: To explore whether type 2 diabetes (T2D) is a risk factor for dementia conversion in patients with mild cognitive impairment (MCI). Methods: A longitudinal nested case-control study in which 101 T2D patients and 101 non-diabetic patients with MCI matched by age and gender were included. Results: The dementia conversion rate was 57.4% in T2D patients vs. 42.6% in non-diabetic subjects (p = 0.02).T2D and APOE epsilon 4 allele were independent risk factors for developing dementia. Conclusion: T2D is an independent risk factor for dementia conversion in MCI patients. This finding has significant clinical implications. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：1272 / 1274
页数：3
相关论文
共 50 条
  • [1] Uric acid index is a risk for mild cognitive impairment in type 2 diabetes
    Tong, Xue-Wei
    Zhang, Yi-Tong
    Li, Xin
    Yu, Zi-Wei
    Pu, Sheng-Dan
    Xu, Yu-Xin
    Shan, Yong-Yan
    Gao, Xin-Yuan
    HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 2023, 22 (03): : 425 - 439
  • [2] Risk of developing dementia in people with diabetes and mild cognitive impairment
    Velayudhan, Latha
    Poppe, Michaela
    Archer, Nicola
    Proitsi, Petroula
    Brown, Richard G.
    Lovestone, Simon
    BRITISH JOURNAL OF PSYCHIATRY, 2010, 196 (01) : 36 - 40
  • [3] Type 2 diabetes and risk of cognitive impairment and dementia
    Whitmer, Rachel A.
    CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2007, 7 (05) : 373 - 380
  • [4] Conversion of amnestic Mild Cognitive Impairment to Dementia of Alzheimer type is independent to memory deterioration
    Rozzini, Luca
    Chilovi, Barbara Vicini
    Conti, Marta
    Bertoletti, Erik
    Delriol, Ilenia
    Trabucchi, Marco
    Padovani, Alessandro
    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2007, 22 (12) : 1217 - 1222
  • [5] Type 2 Diabetes and Mild Cognitive Impairment
    Qu Mei-Hua
    Fang Chun-Yan
    Zhang Xiu-Rong
    Zhao Chun-Zhen
    Mao Shu-Mei
    Gao Zhi-Qin
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2012, 39 (08) : 791 - 795
  • [6] Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies
    Cheng, G.
    Huang, C.
    Deng, H.
    Wang, H.
    INTERNAL MEDICINE JOURNAL, 2012, 42 (05) : 484 - 491
  • [7] Investigation of risk factors for the conversion of mild cognitive impairment to dementia
    Hu, Chengping
    Wang, Ling
    Zhao, Xudong
    Zhu, Binggen
    Tian, Ming
    Qin, Hongyun
    INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2021, 131 (12) : 1173 - 1180
  • [8] Risk of Conversion to Dementia in a Mild Behavioral Impairment Group Compared to a Psychiatric Group and to a Mild Cognitive Impairment Group
    Taragano, Fernando E.
    Allegri, Ricardo F.
    Heisecke, Silvina L.
    Martelli, Maria I.
    Feldman, Monica L.
    Sanchez, Viviana
    Garcia, Virginia A.
    Tufro, Graciela
    Castro, Diego M.
    Perez Leguizamon, Patricio
    Guelar, Veronica
    Ruotolo, Eva
    Zegarra, Cecilia
    Dillon, Carol
    JOURNAL OF ALZHEIMERS DISEASE, 2018, 62 (01) : 227 - 238
  • [9] Risk Factors for Cognitive Impairment in Patients with Type 2 Diabetes
    Sun, Lin
    Diao, Xue
    Gang, Xiaokun
    Lv, You
    Zhao, Xue
    Yang, Shuo
    Gao, Ying
    Wang, Guixia
    JOURNAL OF DIABETES RESEARCH, 2020, 2020
  • [10] HYPOGLYCEMIA AND THE RISK OF COGNITIVE IMPAIRMENT AND DEMENTIA IN ELDERLY AND SENILE PATIENTS WITH TYPE 2 DIABETES
    Ostrounnova, Olga D.
    Surkova, Elena, V
    Goloborodova, Irina, V
    Starodubova, Antonina, V
    Kochetkov, Alexey, I
    Kiknadze, Tamara D.
    Galstayn, Gagik R.
    DIABETES MELLITUS, 2020, 23 (01): : 72 - 87
12345