Highly stable pyrimidine-motif triplex formation at physiological pH values by a bridged nucleic acid analogue

被引：44
作者：
Rahman, S. M. Abdur
Seki, Sayori
Obika, Satoshi
Haitani, Sunao
Miyashita, Kazuyuki
Imanishi, Takeshi
机构：
[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan
[2] JST, PRESTO, Saitama 3320012, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 23期
关键词：
bridged nucleic acids; oligonucleotides; synthesis design; thermal stability; triplexes;
D O I：
10.1002/anie.200604857
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Good things come in threes: A novel bridged nucleic acid in which the furanose conformation was locked in the N form by a six-membered bridged moiety containing an N-O bond (see picture) has been developed. Triplex-forming oligonucleotides composed of this residue formed highly stable triplexes at physiological pH values. (Figure Presented) © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：4306 / 4309
页数：4
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