Targeting DNA repair in precision medicine

被引：10

作者：

Beggs, Reena ^{[1
]}

Yang, Eddy S. ^{[1
,2
]}

机构：

[1] Univ Alabama Birmingham, Sch Med, Dept Radiat Oncol, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Sch Med, Hugh Kaul Precis Med Inst, Birmingham, AL 35294 USA

来源：

DNA REPAIR | 2019年 / 115卷

关键词：

ABDOMINAL RADIATION-THERAPY; ADVANCED SOLID MALIGNANCIES; NUCLEOTIDE EXCISION-REPAIR; DEPENDENT PROTEIN-KINASE; DOUBLE-STRAND BREAKS; CELL LUNG-CANCER; HOMOLOGOUS RECOMBINATION; PHASE-I; VELIPARIB ABT-888; DAMAGE RESPONSE;

D O I：

10.1016/bs.apcsb.2018.10.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Precision medicine is an emerging treatment paradigm that aims to find the right therapy at the right time based on an individual's unique genetic background, environment, and lifestyle. One area of precision medicine that has had success is targeting DNA repair in cancer. DNA is exposed to constant stress and there are repair mechanisms in place to maintain genetic integrity. These repair mechanisms can be targeted as a treatment strategy. In this chapter, we will focus on current efforts to target DNA repair pathways as part of precision oncology-based treatments.

引用

页码：135 / 155

页数：21

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