Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex

被引：35

作者：

Tresserra-Rimbau, Anna ^{[1
,2
,3
,4
]}

Castro-Barquero, Sara ^{[1
,5
]}

Vitelli-Storelli, Facundo ^{[6
]}

Becerra-Tomas, Nerea ^{[1
,2
,3
,4
]}

Vazquez-Ruiz, Zenaida ^{[1
,7
]}

Diaz-Lopez, Andres ^{[1
,2
,3
,4
]}

Corella, Dolores ^{[1
,8
]}

Castaner, Olga ^{[1
,9
]}

Romaguera, Dora ^{[1
,10
]}

Vioque, Jesus ^{[11
,12
]}

Maria Alonso-Gomez, Angel ^{[1
,13
,14
,15
]}

Warnberg, Julia ^{[1
,16
]}

Alfredo Martinez, Jose ^{[1
,7
,17
,18
]}

Serra-Majem, Lluis ^{[1
,19
,20
]}

Estruch, Ramon ^{[1
,21
]}

Jose Tinahones, Francisco ^{[1
,22
]}

Lapetra, Jose ^{[1
,23
]}

Pinto, Xavier ^{[1
,24
]}

Tur, Josep Antoni ^{[1
,10
,25
]}

Lopez-Miranda, Jose ^{[1
,26
]}

Garcia-Molina, Laura ^{[11
,27
]}

Delgado-Rodriguez, Miguel ^{[11
,28
]}

Matia-Martin, Pilar ^{[29
]}

Daimiel, Lidia ^{[18
]}

Rubin-Garcia, Maria ^{[6
]}

Vidal, Josep ^{[30
,31
]}

Galdon, Alba ^{[32
]}

Ros, Emilio ^{[1
,33
]}

Javier Basterra-Gortari, Francisco ^{[1
,7
,34
]}

Babio, Nancy ^{[1
,2
,3
,4
]}

Vicente Sorli, Jose ^{[1
,8
]}

Hernaez, Alvaro ^{[1
,21
]}

Konieczna, Jadwiga ^{[1
,10
]}

Notario-Barandiaran, Leyre ^{[12
]}

Tojal-Sierra, Lucas ^{[1
,13
,14
,15
]}

Perez-Lopez, Jessica ^{[16
]}

Abete, Itziar ^{[1
,17
,18
]}

Alvarez-Perez, Jacqueline ^{[1
,19
,20
]}

Carlos Fernandez-Garcia, Jose ^{[1
,22
]}

Manuel Santos-Lozano, Jose ^{[1
,23
]}

Galera-Cusi, Ana ^{[1
,24
]}

Julibert, Alicia ^{[1
,10
,25
]}

Ruiz-Canela, Miguel ^{[1
,7
]}

Martinez-Lacruz, Raul ^{[1
,8
]}

Perez-Vega, Karla-Alejandra ^{[9
]}

Maria Galmes-Panades, Aina ^{[1
,10
]}

Pastor-Polo, Concepcion ^{[35
]}

Moreno-Rodriguez, Anai ^{[1
,13
,14
,15
]}

Gea, Alfredo ^{[1
,7
]}

Fito, Montserrat ^{[1
,9
]}

机构：

[1] Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain

[2] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr, Reus 43204, Spain

[3] Univ Hosp St Joan de Reus, Nutr Unit, Reus 43201, Spain

[4] IISPV, Reus 43201, Spain

[5] Univ Barcelona, Fac Med & Hlth Sci, Dept Med, E-08036 Barcelona, Spain

[6] Univ Leon, Inst Biomed IBIOMED, Leon 24071, Spain

[7] Univ Navarra, Dept Prevent Med & Publ Hlth, IDISNA, Pamplona 31008, Spain

[8] Univ Valencia, Dept Prevent Med, Valencia 46010, Spain

[9] Inst Hosp Mar Invest Med IMIM, Cardiovasc Risk & Nutr Grp, Barcelona 08007, Spain

[10] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain

[11] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[12] Miguel Hernandez Univ, ISABIAL FISABIO, Alicante 03010, Spain

[13] Bioaraba Hlth Res Inst, Vitoria 01009, Spain

[14] Araba Univ Hosp, Osakidetza Basque Hlth Serv, Vitoria 01009, Spain

[15] Univ Basque Country, UPV EHU, Vitoria 01009, Spain

[16] Univ Malaga, Dept Nursing, Inst Biomed Res Malaga IBIMA, Malaga 29010, Spain

[17] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain

[18] CEI UAM, IMDEA Food, Nutr Genom & Epigenom Grp, CSIC, Madrid 28049, Spain

[19] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria 35016, Spain

[20] Canarian Hlth Serv, CHUIMI, Las Palmas Gran Canaria 35016, Spain

[21] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, E-08036 Barcelona, Spain

[22] Univ Malaga, Virgen de la Victoria Hosp, Dept Endocrinol, Inst Invest Biomed Malaga IBIMA, Malaga 29010, Spain

[23] Dist Sanitario Atenc Primaria Sevilla, Res Unit, Dept Family Med, Seville 41010, Spain

[24] Univ Barcelona, Lipids & Vasc Risk Unit, Internal Med, Hosp Univ Bellvitge,Idibell, E-08908 Lhospitalet De Llobregat, Spain

[25] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain

[26] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med, Cordoba 14004, Spain

[27] Univ Granada, Dept Prevent Med & Publ Hlth, Granada 18016, Spain

[28] Univ Jaen, Fac Med, Div Prevent Med, Jaen 23071, Spain

[29] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid 28040, Spain

[30] ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid 28029, Spain

[31] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, E-08036 Barcelona, Spain

[32] Hosp Univ Fdn Jimenez Diaz, Madrid 28040, Spain

[33] Hosp Clin Barcelona, Inst Investigac Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona 08036, Spain

[34] Hosp Reina Sofia, Dept Internal Med Endocrinol, Tudela 31500, Spain

[35] Ctr Salud Raval Elche, Alicante 03203, Spain

[36] Univ Barcelona, Sch Pharm & Food Sci, Dept Nutr Food Sci & Gastron, XaRTA,INSA, E-08028 Barcelona, Spain

来源：

ANTIOXIDANTS | 2019年 / 8卷 / 11期

基金：

欧洲研究理事会;

关键词：

diet; obesity; flavonoids; catechins; proanthocyanidins; hydroxybenzoic acids; hydroxycinnamic acids; lignans; phenolic acids; 2; COHORTS; PREVENTION; RISK; METABOLITES; BIOMARKERS; MANAGEMENT; MEN;

D O I：

10.3390/antiox8110537

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse associations.

引用

页数：17

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