Genetic hitchhiking versus background selection: the controversy and its implications

被引:116
作者
Stephan, Wolfgang [1 ]
机构
[1] Univ Munich, Sect Evolutionary Biol, Dept Biol 2, D-82152 Planegg Martinsried, Germany
关键词
background selection; genetic hitchhiking; reduction of nucleotide diversity in regions of restricted recombination; selective sweeps; adaptation; STRONG POSITIVE SELECTION; DROSOPHILA-MELANOGASTER; DNA POLYMORPHISM; RECOMBINATION RATES; NATURAL-SELECTION; NUCLEOTIDE POLYMORPHISM; MOLECULAR EVOLUTION; CENTROMERIC REGION; SEGREGATING SITES; CROSSING-OVER;
D O I
10.1098/rstb.2009.0278
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The controversy on the relative importance of background selection (BGS; against deleterious mutations) and genetic hitchhiking (associated with positive directional selection) in explaining patterns of nucleotide variation in natural populations stimulated research activities for almost a decade. Despite efforts from many theorists and empiricists, fundamental questions are still open, in particular, for the population genetics of regions of reduced recombination. On the other hand, the development of the BGS and hitchhiking models and the long struggle to distinguish them, all of which seem to be a purely academic exercise, led to quite practical advances that are useful for the identification of genes involved in adaptation and domestication.
引用
收藏
页码:1245 / 1253
页数:9
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