Antigen receptor genes and the evolution of a recombinase

被引：57

作者：

Schatz, DG ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06510 USA

来源：

SEMINARS IN IMMUNOLOGY | 2004年 / 16卷 / 04期

关键词：

immunoglobulin; T-cell receptor; V(D)J recombination; recombination activating gene; transposition;

D O I：

10.1016/j.smim.2004.08.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antigen receptor genes exist in the germline in a "split" configuration and are assembled in developing B and T lymphocytes by V(D)J recombination. This site-specific recombination reaction is initiated by a complex containing the RAG1 and RAG2 proteins and completed by general DNA repair factors. RAG1 and RAG2, like the adaptive immune system itself, are found exclusively in jawed vertebrates, and are thought to have entered the vertebrate genome by horizontal transmission as components of a transposable element. This review discusses the structure of antigen receptor genes and the mechanisms by which they are assembled and diversified, and then goes on to consider the evolutionary implications of the arrival of the hypothetical "RAG transposon". (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：245 / 256

页数：12

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