Cytotoxic steroidal saponins from Polygonatum zanlanscianense

被引：32

作者：

Jin, JM ^{[1
]}

Zhang, YJ ^{[1
]}

Li, HZ ^{[1
]}

Yang, CR ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources, Kunming 650204, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 12期

关键词：

D O I：

10.1021/np049897u

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new steroidal saponins, polygonatosides A-D (1-4), were isolated from the rhizomes of Polygonatum zanlanscianense, together with six known spirostanols (5-10) and a known megastigmane glycoside (11). Their structures were elucidated on the basis of spectroscopic analysis and the results of acidic and enzymatic hydrolysis. The cytotoxic activities of 1-11 against HeLa cells are described.

引用

页码：1992 / 1995

页数：4

共 25 条

[1] BARBOURGENIN, A NEW STEROIDAL SAPOGENIN FROM AGAVE-SISALANA LEAVES [J].

BLUNDEN, G ;

PATEL, AV ;

CRABB, TA .

JOURNAL OF NATURAL PRODUCTS, 1986, 49 (04) :687-689

[2] A steroidal glycoside from Polygonatum odoratum (Mill.) Druce. improves insulin resistance but does not alter insulin secretion in 90% pancreatectomized rats [J].

Choi, SB ;

Park, S .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2002, 66 (10) :2036-2043

[3]

FAWKEYA A, 2000, B FAC PHARM, V38, P147

[4] NEW SOURCES OF STEROID SAPOGENINS .27. 27-HYDROXYRUSCOGENIN, A NEW SPIROSTAN SAPOGENIN FROM SEMELE-ANDROGYNA [J].

GONZALEZ, AG ;

FRANCISCO, CG ;

FRIERE, R ;

HERNANDEZ, R ;

SALAZAR, JA ;

SUAREZ, E .

PHYTOCHEMISTRY, 1975, 14 (10) :2257-2258

[5] Antineoplastic agents .1. Three Spirostanol glycosides from rhizomes of Dioscorea collettii var hypoglauca [J].

Hu, K ;

Dong, AJ ;

Yao, XS ;

Kobayashi, H ;

Iwasaki, S .

PLANTA MEDICA, 1996, 62 (06) :573-575

[6]

Huang PL, 1997, PHYTOCHEMISTRY, V44, P1369

[7] A NEW STEREOIDAL SAPONIN FROM POLYGONATUM-OFFICINALE [J].

JANECZKO, Z ;

JANSSON, PE ;

SENDRA, J .

PLANTA MEDICA, 1987, (01) :52-54

[8]

*JIANGS I BOT, 1991, XINH BENC GANGY, V2, P507

[9]

*JIANGS NEW MED CO, 1977, DICT CHIN HERB MED, P2041

[10] Spirostanol and furostanol glycosides from the fresh tubers of Polianthes tuberosa [J].

Jin, JM ;

Zhang, YJ ;

Yang, CR .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (01) :5-9

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