Decorative Multi-Walled Carbon Nanotubes by ZnO: Synthesis, Characterization, and Potent Anti-Toxoplasmosis Activity

被引：12

作者：

Al-Humaidi, Jehan Y. ^{[1
]}

Hagar, Mohamed ^{[2
]}

Bakr, Basant A. ^{[3
]}

Elwakil, Bassma H. ^{[4
]}

Moneer, Esraa Abdelhamid ^{[4
]}

El-Khatib, Mostafa ^{[5
]}

机构：

[1] Princess Nourah Bint Abdulrahman Univ, Coll Sci, Dept Chem, POB 84428, Riyadh 11671, Saudi Arabia

[2] Alexandria Univ, Fac Sci, Dept Chem, Alexandria 21321, Egypt

[3] Alexandria Univ, Fac Sci, Dept Zool, Alexandria 21321, Egypt

[4] Pharos Univ Alexandria, Fac Appl Hlth Sci Technol, Dept Med Lab Technol, Alexandria 21526, Egypt

[5] Pharos Univ Alexandria, Fac Engn, Basic Sci Dept, Alexandria 21526, Egypt

来源：

METALS | 2022年 / 12卷 / 08期

关键词：

arc discharge; nanostructures; ZnO-MWCNT; antiparasitic; Toxoplasma gondii; in vivo study; immunological studies; ARC-DISCHARGE; ANTIBACTERIAL; NANOPARTICLES;

D O I：

10.3390/met12081246

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Toxoplasmosis may become a fatal disease in immunodeficient, diabetic patients, pregnant women, and infants. Hence, the diligent search for new effective treatment is among the major concerns worldwide. The well-dispersed multi-walled carbon nanotubes lined with ZnO (ZnO-MWCNT), graphene oxide (GO-NPs), and zinc oxide (ZnO-NPs) were successfully synthesized through rapid and facile hydrothermal arc discharge technique (HTADT). The antiparasitic effects of ZnO-NPs, GO-NPs, and ZnO-MWCNT were investigated in mice infected with Toxoplasma gondii. The percent of tachyzoites reduction were detected. The observed results demonstrated that ZnO-MWCNT revealed a significant reduction in the parasite count reached 61% in brain tissues, followed by liver (52%), then spleen (45%). The assessments of antiparasitic, inflammatory, and anti-inflammatory cytokines confirmed the superior activity of ZnO-MWCNT as antiparasitic agent, which paves the way for the employment of ZnO-MWCNT as a treatment for the acute RH strain of T. gondii infection in vivo.

引用

页数：14

共 40 条

[1] Water Treatment from MB Using Zn-Ag MWCNT Synthesized by Double Arc Discharge [J].