What role does dopamine really play in tobacco addiction?

被引：2
|
作者：
Chiamulera, Cristiano [1 ]
West, Robert J. [2 ]
机构：
[1] Univ Verona, Pharmacol Sect, Dept Diagnost & Publ Hlth, Verona, Italy
[2] UCL, Dept Behav Sci & Hlth, London, England
来源：
ADDICTION | 2018年 / 113卷 / 08期
基金：
英国医学研究理事会;
关键词：
Addiction; dopamine; nicotine; smoking; smoking cessation; tobacco; MESOLIMBIC DOPAMINE; NICOTINE; MECHANISMS;
D O I：
10.1111/add.14235
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
A prevailing narrative explaining tobacco addiction is that uptake of nicotine in the brain causes dopamine release in the nucleus accumbens which rewards the behaviour that led to it. However, evidence suggests that in this and other addictive disorders a more nuanced and multi-level model is required that recognizes how dopamine interacts with other parts of a complex system to maintain maladaptive behaviour patterns.
引用
收藏
页码：1379 / 1380
页数：2
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