Diketopyrrolopyrrole-Porphyrin Conjugates with High Two-Photon Absorption and Singlet Oxygen Generation for Two-Photon Photodynamic Therapy

被引：231

作者：

Schmitt, Julie ^{[1
]}

Heitz, Valerie ^{[1
]}

Sour, Angelique ^{[1
]}

Bolze, Frederic ^{[2
]}

Ftouni, Hussein ^{[2
]}

Nicoud, Jean-Francois ^{[2
]}

Flamigni, Lucia ^{[3
]}

Ventura, Barbara ^{[3
]}

机构：

[1] CNRS, Inst Chim Strasbourg, LSAMM, UMR 7177, F-67000 Strasbourg, France

[2] CNRS, UdS, CAMB, UMR 7199,Fac Pharm, F-67401 Illkirch Graffenstaden, France

[3] Ist ISOF CNR, I-40129 Bologna, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 01期

关键词：

diketopyrroles; dyes/pigments; photodynamic therapy; porphyrins; singlet oxygen; two-photon absorption; SENSITIZED SOLAR-CELLS; PI-EXPANDED DIKETOPYRROLOPYRROLES; NONLINEAR-OPTICAL PROPERTIES; ZINC PORPHYRIN; FLUORESCENCE; MICROSCOPY; EXCITATION; MOLECULES; OLIGOMERS; POLYMER;

D O I：

10.1002/anie.201407537

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two-photon photodynamic therapy is a promising therapeutic method which requires the development of sensitizers with efficient two-photon absorption and singlet-oxygen generation. Reported here are two new diketopyrrolopyrrole-porphyrin conjugates as robust two-photon absorbing dyes with high two-photon absorption cross-sections within the therapeutic window. Furthermore, for the first time the singlet-oxygen generation efficiency of diketopyrrolopyrrole-containing systems is investigated. A preliminary study on cell culture showed efficient two-photon induced phototoxicity.

引用

页码：169 / 173

页数：5

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