Gastroenteritis and antibiotic-associated diarrhea

Acute gastroenteritis is a common cause of emergency and office visits. This article reviews causes, pathogenesis, diagnosis, prevention, and treatment. The incidence of antibiotic-associated colitis is increasing worldwide as a consequence of widespread use of broad-spectrum antibiotics for various illnesses. The pathogenic organism, Clostridium difficile, produces two enterotoxins, toxin A and toxin B, that cause colonic mucosal inflammation. C. difficile infection presents with a wide range of clinical manifestations, from asymptomatic carriers to life-threatening pseudomembranous colitis.