The permease homologue Ssy1p controls the expression of amino acid and peptide transporter genes in Saccharomyces cerevisiae

被引：181

作者：

Didion, T ^{[1
]}

Regenberg, B ^{[1
]}

Jorgensen, MU ^{[1
]}

Kielland-Brandt, MC ^{[1
]}

Andersen, HA ^{[1
]}

机构：

[1] Carlsberg Lab, Dept Yeast Genet, DK-2500 Copenhagen, Denmark

来源：

MOLECULAR MICROBIOLOGY | 1998年 / 27卷 / 03期

关键词：

D O I：

10.1046/j.1365-2958.1998.00714.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amino acid transporters of the yeast plasma membrane (permeases) belong to a family of integral membrane proteins with pronounced structural similarity. We present evidence that a member of this family, encoded by the open reading frame (ORF) YDR160w (SSY1), is required for the expression of a set of transporter genes, Thus, deletion of the SSY1 gene causes loss of leucine-inducible transcription of the amino acid permease genes BAP2, TATI and BAP3 (ORF YDR046c) and the peptide transporter, PTR2. D-leucine can generate the signal without entering the cell. We propose that Ssy1p is situated in the plasma membrane and is involved in sensing leucine in the medium.

引用

页码：643 / 650

页数：8

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