From kidney to cardiovascular diseases: NGAL as a biomarker beyond the confines of nephrology

被引：89
作者：
Bolignano, D. [1 ]
Coppolino, G. [1 ]
Lacquaniti, A. [1 ]
Buemi, M. [1 ]
机构：
[1] Univ Messina, Dept Internal Med, Chair Nephrol, Messina, Italy
来源：
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 2010年 / 40卷 / 03期
关键词：
Atherosclerosis; cardiovascular disease; cardiovascular risk; neutrophil gelatinase-associated lipocalin; GELATINASE-ASSOCIATED LIPOCALIN; CORONARY-ARTERY-DISEASE; CHRONIC HEART-FAILURE; LEUKOCYTE ACTIVATION; RENAL-FUNCTION; INFLAMMATORY MEDIATORS; MARKER; ATHEROSCLEROSIS; PLASMA; EXPRESSION;
D O I：
10.1111/j.1365-2362.2010.02258.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
P>Neutrophil gelatinase-associated lipocalin (NGAL), a small 25 kDa stress-protein released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. This brief review explores the new interesting involvement of NGAL in the experimental and clinical field of cardiovascular diseases, such as the pathogenesis and clinical manifestations of atherosclerosis, acute myocardial infarction and heart failure. It does not seem difficult that, in the next future, NGAL may become a new missing link between the kidney and the cardiovascular system.
引用
收藏
页码：273 / 276
页数：4
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