Visible-light induced C3-H trifluoromethylation of quinoxalin-2(1H)-ones with CF3SO2Cl under external photocatalyst-free conditions

被引：16

作者：

Mi, Xia ^{[1
]}

Cui, Beibei ^{[1
]}

Zhang, Jingyu ^{[1
]}

Pi, Chao ^{[2
]}

Cui, Xiuling ^{[2
]}

机构：

[1] Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450046, Peoples R China

[2] Zhengzhou Univ, Key Lab Appl Chem,Henan Univ, Coll Chem,Henan Key Lab Chem Biol & Organ Chem, Green Catalysis Ctr, Zhengzhou 450052, Peoples R China

来源：

TETRAHEDRON LETTERS | 2022年 / 93卷

基金：

中国国家自然科学基金;

关键词：

Photocatalyst-free; Quinoxalin-2(1H)-ones; Visible light; Trifluoromethylation; FLUOROALKYLATION REACTIONS; ADDITIVE-FREE; METAL; FUNCTIONALIZATION; FLUORINE; DESIGN; HETEROARENES; DERIVATIVES; INHIBITORS; ALKENES;

D O I：

10.1016/j.tetlet.2022.153693

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reported herein is a visible light-induced C-H trifluoromethylation of quinoxalin-2(1H)-ones with CF3SO2Cl as CF3 radical source under photocatalyst-free conditions. The reaction proceeds smoothly through a radical process in the absence of photocatalyst and oxidant in moderate to good yields, thus offering an efficient and green method for the synthesis of 3-trifluoromethyl quinoxalin-2(1H)-ones.(C) 2022 Elsevier Ltd. All rights reserved.

引用

页数：4

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