FGF19 Contributes to Tumor Progression in Gastric Cancer by Promoting Migration and Invasion

被引：15

作者：

Wang, Shuang ^{[1
]}

Zhao, Daqi ^{[2
]}

Tian, Ruihua ^{[1
]}

Shi, Hailong ^{[1
]}

Chen, Xiangming ^{[1
]}

Liu, Wenzhi ^{[1
]}

Wei, Lin ^{[1
]}

机构：

[1] Cent Hosp Taian, Dept Clin Oncol, Longtan Rd 29, Tai An 271000, Shandong, Peoples R China

[2] Cent Hosp Taian, Dept Radiat Oncol, Tai An, Shandong, Peoples R China

来源：

ONCOLOGY RESEARCH | 2016年 / 23卷 / 04期

关键词：

Gastric cancer; FGF19; Migration; Invasion; HEPATOCELLULAR-CARCINOMA; GROWTH; EXPRESSION; FIBROBLAST-GROWTH-FACTOR-19; KLOTHO;

D O I：

10.3727/096504016X14537290676919

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastric cancer is the fourth most common type of cancer and second leading cause of cancer-related death in the world. Since patients are often diagnosed at a late stage, very few effective therapies are left in the arsenal. FGF19, as a hormone, has been reported to promote tumor growth in various types of cancers however, its function in gastric cancer remains unknown. In the current study, we showed that FGF19 is overexpressed in gastric cancer and is associated with depth of invasion, lymph node metastasis, and TNM stage. In addition, in vitro experiments demonstrated that FGF19 is able to enhance migration and invasion abilities of gastric cancer cells. Given its great potency in gastric cancer progression, FGF19 may be an effective target of treatment for advanced gastric cancer patients.

引用

页码：197 / 203

页数：7

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