The Role of Six1 in the Genesis of Muscle Cell and Skeletal Muscle Development

被引：35

作者：

Wu, Wangjun ^{[1
,2
]}

Huang, Ruihua ^{[1
,2
]}

Wu, Qinghua ^{[3
,4
]}

Li, Pinghua ^{[1
,2
]}

Chen, Jie ^{[1
]}

Li, Bojiang ^{[1
]}

Liu, Honglin ^{[1
]}

机构：

[1] Nanjing Agr Univ, Dept Anim Genet Breeding & Reprod, Coll Anim Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China

[2] Huaian Acad, Nanjing Agr Univ, Huaian 223001, Jiangsu, Peoples R China

[3] Yangtze Univ, Coll Life Sci, Jinzhou 434023, Hubei, Peoples R China

[4] Univ Hradec Kradec Kralove, Fac Informat & Management, Ctr Basic & Appl Res, Hradec Kralove, Czech Republic

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2014年 / 10卷 / 09期

关键词：

Six1; Muscle; Muscle fiber; Muscle progenitors; Regulatory network; Molecular mechanism; MYOGENIC PRECURSOR CELLS; PROTEINS SINE-OCULIS; C-MET RECEPTOR; 6 FAMILY GENES; EYE DEVELOPMENT; HOMEOBOX GENES; TRANSCRIPTION FACTORS; HOMEODOMAIN-PROTEINS; FIBER-TYPE; MYOTONIC-DYSTROPHY;

D O I：

10.7150/ijbs.9442

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sine oculis homeobox 1 (Six1) gene encodes an evolutionarily conserved transcription factor. In the past two decades, much research has indicated that Six1 is a powerful regulator participating in skeletal muscle development. In this review, we summarized the discovery and structural characteristics of Six1 gene, and discussed the functional roles and molecular mechanisms of Six1 in myogenesis and in the formation of skeletal muscle fibers. Finally, we proposed areas of future interest for understanding Six1 gene function.

引用

页码：983 / 989

页数：7

共 81 条

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