Rothmund-Thomson syndrome helicase, RECQ4: On the crossroad between DNA replication and repair

被引：36

作者：

Liu, Yilun ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06510 USA

来源：

DNA REPAIR | 2010年 / 9卷 / 03期

关键词：

RECQ protein; Rothmund-Thomson syndrome; Baller-Gerold syndrome; BALLER-GEROLD-SYNDROME; SYNDROME GENE-PRODUCT; END RULE PATHWAY; FANCONI-ANEMIA; RAPADILINO-SYNDROME; SYNDROME PROTEIN; HUMAN-CELLS; HYDROCEPHALUS; ASSOCIATION; CAPACITY;

D O I：

10.1016/j.dnarep.2010.01.006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

RECQ proteins are conserved DNA helicases in both prokaryotes and eukaryotes. The importance of the RECQ family helicases in human health is demonstrated by their roles as cancer suppressors that are vital for preserving genome integrity. Mutations in one of the RECQ family proteins, RECQ4, not only result in developmental abnormalities and cancer predispositions, but are also linked to premature aging. Therefore, defining the function and regulation of the RECQ4 protein is fundamental to our understanding of both the aging process and cancer pathogenesis. This review will summarize the clinical effect of RECQ4 in human health, and discuss the recent progress and debate in defining the complex molecular function of RECQ4 in DNA metabolism. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：325 / 330

页数：6

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