Toxic myopathies - Muscle biopsy features

被引：6

作者：

Scola, Rosana Herminia ^{[1
]}

Pereira, Eduardo Rafael ^{[1
]}

Lorenzoni, Paulo Jose ^{[1
]}

Werneck, Lineu Cesar ^{[1
]}

机构：

[1] Hosp Clin UFPR, Serv Doencas Neuromusculares, Dept Internal Med, Neuromuscular Neurol Div, BR-80060900 Curitiba, Parana, Brazil

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2007年 / 65卷 / 01期

关键词：

myopathy; drug; iatrogenic myopathy; toxic myopathy; muscle biopsy;

D O I：

10.1590/S0004-282X2007000100018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several drugs and toxic substances can cause muscular abnormalities and are frequent causes of acquired myopathies. We present a series of 32 patients, predominance of young adult patients, diagnosed with toxic myopathy. The most common substances inducing myopathy were corticosteroids (56.2%) followed by the propoxyphene, neuroleptics, zidovudine and drug-induced hypokalemia. The investigation showed normal serum creatine kinase levels in 65.4%, myopathic pattern of the needle electromyography in 40% and the more frequent histological diagnosis of the muscle biopsy was type 2 fiber atrophy (59.3%). Clinical features, etiology, course of the disease, serum levels of muscular enzymes, electromyographic features and, especially, muscle biopsy features are discussed.

引用

页码：82 / 86

页数：5

共 23 条

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