Child physical activity as a modifier of the relationship between prenatal exposure to maternal overweight/obesity and neurocognitive outcomes in offspring

被引：3

作者：

Alves, Jasmin M. ^{[1
,2
]}

Angelo, Brendan C. ^{[1
,2
]}

Zink, Jennifer ^{[3
]}

Chow, Ting ^{[4
]}

Yunker, Alexandra G. ^{[1
,2
]}

Clark, Kristi ^{[5
]}

Luo, Shan ^{[1
,2
]}

Belcher, Britni Ryan ^{[3
]}

Herting, Megan M. ^{[3
]}

Dieli-Conwright, Christina M. ^{[6
]}

Xiang, Anny H. ^{[4
]}

Page, Kathleen A. ^{[1
,2
]}

机构：

[1] Univ Southern Calif, Keck Sch Med, Dept Med, Div Endocrinol, Los Angeles, CA 90007 USA

[2] Univ Southern Calif, Keck Sch Med, Diabet & Obes Res Inst, Los Angeles, CA 90089 USA

[3] Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90007 USA

[4] Kaiser Permanente Southern Calif, Dept Res & Evaluat, Pasadena, CA 91101 USA

[5] Univ Southern Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90089 USA

[6] Harvard Med Sch, Dana Farber Inst, Dept Med Oncol, Div Populat Sci, Boston, MA 02215 USA

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2021年 / 45卷 / 06期

基金：

美国国家卫生研究院;

关键词：

BRAIN WHITE-MATTER; BODY-MASS INDEX; ACADEMIC-ACHIEVEMENT; INSULIN SENSITIVITY; ACTIVITY INTERVENTION; EXECUTIVE FUNCTION; PUBERTAL CHANGES; AEROBIC FITNESS; ACTIVITY RECALL; SEX-DIFFERENCES;

D O I：

10.1038/s41366-021-00794-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/Objectives With rising obesity rates among pregnant women, more children are exposed in utero to maternal obesity. In prior epidemiological studies, exposure to maternal obesity was associated with lower intelligence quotient (IQ) scores and worse cognitive abilities in offspring. Further studies have shown that offspring exposed to maternal obesity, exhibit differences in the white matter microstructure properties, fractional anisotropy (FA) and mean diffusivity (MD). In contrast, physical activity was shown to improve cognition and white matter microstructure during childhood. We examined if child physical activity levels modify the relationship between prenatal exposure to maternal obesity with IQ and white matter microstructure in offspring. Subjects/Methods One hundred children (59% girls) age 7-11 years underwent brain magnetic resonance imaging and IQ testing. Maternal pre-pregnancy BMI was abstracted from electronic medical records. White matter was assessed using diffusion tensor imaging with the measures, global FA, MD. The 3-day physical activity recall was used to measure moderate-to-vigorous physical activity and vigorous physical activity (VPA). Linear regression was used to test for interactions between prenatal exposure to maternal overweight/obesity and child PA levels on child IQ and global FA/MD. Results The relationship between prenatal exposure to maternal overweight/obesity and child IQ and global FA varied by child VPA levels. Children exposed to mothers with overweight/obesity who engaged in more VPA had higher IQ scores and global FA compared to exposed children who engaged in less VPA. Associations were independent of child age, sex, BMI Z-score and socioeconomic status. Children born to normal-weight mothers did not differ in either IQ or global FA by time in VPA. Conclusions Our findings support findings in rodent models and suggest that VPA during childhood modifies the relationship between prenatal exposure to maternal obesity and child IQ and white matter microstructure.

引用

页码：1310 / 1320

页数：11

共 74 条

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