Indwelling Stent Embedded with Light-Emitting Diodes for Photodynamic Therapy of Malignant Biliary Obstruction

被引：3

作者：

Baran, Timothy M. ^{[1
]}

Mironov, Oleg ^{[2
]}

Sharma, Ashwani K. ^{[1
]}

Foster, Thomas H. ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Dept Imaging Sci, 601 Elmwood Ave, Rochester, NY 14642 USA

[2] Univ Hlth Network, Joint Dept Med Imaging, 700 Univ Ave, Toronto, ON M5G 1X6, Canada

来源：

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY | 2016年 / 39卷 / 06期

关键词：

Catheter drainage; Interventional oncology; Bileduct; Biliary; Cancer; CHOLANGIOCARCINOMA; PALLIATION; SURVIVAL;

D O I：

10.1007/s00270-015-1241-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe the design and preliminary characterization of a stent incorporating light-emitting diodes (LEDs) for photodynamic therapy (PDT) of malignant biliary obstruction. A prototype was constructed with red (640 nm) LEDs embedded in a 14.5 French polyurethane tube. The device was evaluated for optical power and subjected to physical and electrical tests. PDT-induced reactive oxygen species were imaged in a gel phantom. The stent functioned at a 2.5-cm bend radius and illuminated for 6 months in saline. No stray currents were detected, and it was cool after 30 minutes of operation. Optical power of 5-15 mW is applicable to PDT. Imaging of a reactive oxygen indicator showed LED-stent activation of photosensitizer. The results motivate biological testing and design optimization.

引用

页码：916 / 919

页数：4

共 8 条

[1] Indirect detection of photosensitizer ex vivo [J].

Bourré, L ;

Thibaut, S ;

Briffaud, A ;

Rousset, N ;

Eléouet, S ;

Lajat, Y ;

Patrice, T .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2002, 67 (01) :23-31

[2] Longterm outcome of photodynamic therapy compared with biliary stenting alone in patients with advanced hilar cholangiocarcinoma [J].

Cheon, Young Koog ;

Lee, Tae Yoon ;

Lee, Seung Min ;

Yoon, Jung Yoon ;

Shim, Chan Sup .

HPB, 2012, 14 (03) :185-193

[3] Biliary stenting: Indications, choice of stents and results: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline [J].

Dumonceau, J. -M. ;

Tringali, A. ;

Blero, D. ;

Deviere, J. ;

Laugiers, R. ;

Heresbach, D. ;

Costamagna, G. .

ENDOSCOPY, 2012, 44 (03) :277-+

[4] Unresectable cholangiocarcinoma: Comparison of survival in biliary stenting alone versus stenting with photodynamic therapy [J].

Kahaleh, Michel ;

Mishra, Rajnish ;

Shami, Vanessa M. ;

Northup, Patrick G. ;

Berg, Carl L. ;

Bashlor, Penny ;

Jones, Petra ;

Ellen, Kristi ;

Weiss, Geoffrey R. ;

Brenin, Christiana M. ;

Kurth, Barbara E. ;

Rich, Tyvin A. ;

Adams, Reid B. ;

Yeaton, Paul .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2008, 6 (03) :290-297

[5] Palliation of Malignant Extrahepatic Biliary Obstruction With Plastic Versus Expandable Metal Stents: An Evidence-Based Approach [J].

Levy, Michael J. ;

Baron, Todd H. ;

Gostout, Christopher J. ;

Petersen, Bret T. ;

Farnell, Michael B. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2004, 2 (04) :273-285

[6] Successful photodynamic therapy for nonresectable cholangiocarcinoma:: A randomized prospective study [J].

Ortner, MEJ ;

Caca, K ;

Berr, F ;

Liebetruth, J ;

Mansmann, U ;

Huster, D ;

Voderholzer, W ;

Schachschal, G ;

Mössner, J ;

Lochs, H .

GASTROENTEROLOGY, 2003, 125 (05) :1355-1363

[7] Surgical and palliative management and outcome in 184 patients with hilar cholangiocarcinoma - Palliative photodynamic therapy plus stenting is comparable to R1/R2 resection [J].

Witzigmann, Helmut ;

Berr, Frieder ;

Ringel, Ulrike ;

Caca, Karel ;

Uhlmann, Dirk ;

Schoppmeyer, Konrad ;

Tannapfel, Andrea ;

Wittekind, Christian ;

Mossner, Joachim ;

Hauss, Johann ;

Wiedmann, Marcus .

ANNALS OF SURGERY, 2006, 244 (02) :230-239

[8] Palliation of nonresectable bile duct cancer: Improved survival after photodynamic therapy [J].

Zoepf, T ;

Jakobs, R ;

Arnold, JC ;

Apel, D ;

Riemann, JF .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2005, 100 (11) :2426-2430

← 1 →