Chitosan Functionalized Magnetic Nanoparticles to Provide Neural Regeneration and Recovery after Experimental Model Induced Peripheral Nerve Injury

被引：21

作者：

Pop, Nadina Liana ^{[1
]}

Nan, Alexandrina ^{[2
]}

Urda-Cimpean, Andrada Elena ^{[3
]}

Florea, Adrian ^{[4
]}

Toma, Vlad Alexandru ^{[5
,6
]}

Moldovan, Remus ^{[1
]}

Decea, Nicoleta ^{[1
]}

Mitrea, Daniela Rodica ^{[1
]}

Orasan, Remus ^{[1
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Physiol, Clinicilor St 1-3, Cluj Napoca 400006, Cluj County, Romania

[2] Natl Inst Res & Dev Isotop & Mol Technol, Donath St 67-103, Cluj Napoca 400293, Cluj County, Romania

[3] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Informat & Biostat, Pasteur St 4-6, Cluj Napoca 400349, Cluj County, Romania

[4] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Cell & Mol Biol, Pasteur St 4-6, Cluj Napoca 400349, Cluj County, Romania

[5] Babes Bolyai Univ, Dept Mol Biol & Biotechnol, Clinicilor St 4-6, Cluj Napoca 400000, Cluj County, Romania

[6] Inst Biol Res, Republicii St 48, Cluj Napoca 400015, Cluj County, Romania

来源：

BIOMOLECULES | 2021年 / 11卷 / 05期

关键词：

functional rehabilitation; peripheral nerve injury; chitosan magnetic nanoparticles; sciatic functional index; IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; WALLERIAN DEGENERATION; NEUROTROPHIC FACTOR; SCHWANN-CELLS; GROWTH-FACTOR; TOXICITY; MEMBRANES; CONDUITS; PATHWAY;

D O I：

10.3390/biom11050676

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(1) Background: Peripheral nerve injuries have a great impact on a patient's quality of life and a generally poor outcome regarding functional recovery. Lately, studies have focused on different types of nanoparticles and various natural substances for the treatment of peripheral nerve injuries. This is the case of chitosan, a natural compound from the crustaceans' exoskeleton. The present study proposes to combine chitosan benefic properties to the nanoparticles' ability to transport different substances to specific locations and evaluate the effects of magnetic nanoparticles functionalized with chitosan (CMNPs) on peripheral nerve injuries' rehabilitation by using an in vivo experimental model. (2) Methods: CMNPs treatment was administrated daily, orally, for 21 days to rats subjected to right sciatic nerve lesion and compared to the control group (no treatment) by analyzing the sciatic functional index, pain level, body weight, serum nerve growth factor levels and histology, TEM and EDX analysis at different times during the study. (3) Results: Animals treated with CMNPs had a statistically significant functional outcome compared to the control group regarding: sciatic functional index, pain-like behavior, total body weight, which were confirmed by the histological and TEM images. (4) Conclusions: The results of the study suggest that CMNPs appear to be a promising treatment method for peripheral nerve injuries.

引用

页数：22

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