Positive impact of long-term lifestyle change on erythrocyte fatty acid profile after acute coronary syndromes

被引：16

作者：

Caspar-Bauguil, Sylvie ^{[1
]}

Garcia, Jesus ^{[1
]}

Galinier, Anne ^{[1
]}

Periquet, Brigitte ^{[1
]}

Ferrieres, Jean ^{[2
]}

Allenbach, Sylvie ^{[1
]}

Morin, Nathalie ^{[1
]}

Hericotte, Pascal ^{[3
]}

Salvayre, Robert ^{[1
]}

Baudet, Marc ^{[3
]}

机构：

[1] CHU Rangueil, Biochim Lab, F-31059 Toulouse 9, France

[2] CHU Rangueil, Serv Cardiol, F-31059 Toulouse 9, France

[3] Hop Dax Cote dArgent, Serv Cardiol, Dax, France

来源：

ARCHIVES OF CARDIOVASCULAR DISEASES | 2010年 / 103卷 / 02期

关键词：

Fatty acids; Erythrocytes; Phospholipids; Acute coronary syndromes; Patient education; Prevention; ALPHA-LINOLENIC ACID; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; HYPERCHOLESTEROLEMIC MEN; ADIPOSE-TISSUE; HEART-DISEASE; DIET; RISK; FISH; DEATH;

D O I：

10.1016/j.acvd.2009.12.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background. - The outcome of coronary diseases is influenced by lifestyle and diet. Among dietary factors, n-3 polyunsaturated fatty acids reduce mortality from cardiovascular diseases. Aims. - To evaluate the impact of dietary and lifestyle advice by calculation of scores and analysis of plasmatic lipids and the fatty acid composition of erythrocyte membrane phospholipids after 1 year of patient education in 66 patients with acute coronary syndromes. Methods. - The answers given by patients during questioning were transformed into scores (atherosclerosis risk, dietary habits and global scores) at inclusion and after 1 year of follow-up. Classical metabolic risk factors and fatty acid composition of erythrocyte phospholipids were determined at the same time. Results. - After 1 year of education, patients improved their different scores, particularly by changing dietary habits. The positive impact was seen in the blood lipid and erythrocyte fatty acid levels: plasma low-density lipoprotein cholesterol and triglyceride concentrations were lowered and n-3 polyunsaturated fatty acid percentages were improved in phospholipids. Conclusion. - Global score, lipid variables and the nature of the polyunsaturated fatty acids in erythrocyte phospholipids help us to evaluate patients with high coronary artery disease risk and the benefits of long-term dietary and lifestyle advice. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：106 / 114

页数：9

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