New icetexane and 20-norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi

被引：93

作者：

Uchiyama, N

Kiuchi, F ^{[1
]}

Ito, M

Honda, G

Takeda, Y

Khodzhimatov, OK

Ashurmetov, OA

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Kyoto 6068501, Japan

[2] Univ Tokushima, Fac Integrated Arts & Sci, Tokushima 7708502, Japan

[3] Uzbek Acad Sci, Sci Prod Ctr Botanika, Tashkent 700143, Uzbekistan

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 01期

关键词：

D O I：

10.1021/np020308z

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new icetexane diterpenes, cyclocoulterone (1) and komaroviquinone (2), and a novel 20-norabietane diterpene, dracocephalone A (3), were isolated from Dracocephalum komaroui. Their structures were elucidated by extensive analyses of spectral data. Komaroviquinone (2) showed strong trypanocidal activity against epmastigotes of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 0.4 muM.

引用

页码：128 / 131

页数：4

共 10 条

[1]

ALPHONSE K, 1983, TETRAHEDRON, V39, P3603

[2]

Anam EM, 1998, INDIAN J CHEM B, V37, P1307

[3]

Bastien Joseph, 1998, The Kiss of Death: Chagas Disease in the Americas

[4] ABIETANE DITERPENOIDS FROM LEPECHINIA-MEYENI AND LEPECHINIA-HASTATA [J].