The gut-brain axis in obesity

被引：59

作者：

Buhmann, Helena ^{[1
]}

le Roux, Care W. ^{[2
,3
]}

Bueter, Marco ^{[4
,5
]}

机构：

[1] Univ Zurich, Vetsuisse Fac, Inst Vet Physiol, CH-8006 Zurich, Switzerland

[2] Univ Coll Dublin, Sch Med & Med Sci, Conway Inst, Diabet Complicat Res Ctr, Dublin, Ireland

[3] Univ Gothenburg, Gastrosurg Lab, Gothenburg, Sweden

[4] Univ Zurich Hosp, Dept Surg, Div Visceral & Transplantat Surg, CH-8091 Zurich, Switzerland

[5] Univ Zurich, Ctr Integrat Human Physiol, Zurich, Switzerland

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2014年 / 28卷 / 04期

基金：

爱尔兰科学基金会;

关键词：

Obesity; Appetite; Gastrointestinal hormones; Glucagon-like-peptide 1 (GLP-1); Hypothalamus; GLUCAGON-LIKE PEPTIDE-1; GASTRIC-INHIBITORY POLYPEPTIDE; REDUCES FOOD-INTAKE; BODY-WEIGHT GAIN; NERVOUS-SYSTEM CONTROL; PLASMA GHRELIN LEVELS; PANCREATIC-POLYPEPTIDE; NEUROPEPTIDE-Y; GLYCEMIC CONTROL; POSTPRANDIAL GLUCOSE;

D O I：

10.1016/j.bpg.2014.07.003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Currently the only effective treatment for morbid obesity with a proven mortality benefit is surgical intervention. The underlying mechanisms of these surgical techniques are unclear, but alterations in circulating gut hormone levels have been demonstrated to be at least one contributing factor. Gut hormones seem to communicate information from the gastrointestinal tract to the regulatory appetite centres within the central nervous system (CNS) via the so-called 'Gut-Brain-Axis'. Such information may be transferred to the CNS either via vagal or non-vagal afferent nerve signalling or directly via blood circulation. Complex neural networks, distributed throughout the forebrain and brainstem, are in control of feeding and energy homoeostasis. This article aims to review how appetite is potentially regulated by these gastrointestinal hormones. Identification of the underlying mechanisms of appetite and weight control may pave the way to develop better surgical techniques and new therapies in the future. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：559 / 571

页数：13

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