Electroconvulsive Seizure Alters the Expression and Daily Oscillation of Circadian Genes in the Rat Frontal Cortex

被引：9

作者：

Kim, Se Hyun ^{[1
]}

Park, Hong Geun ^{[2
]}

Jeong, Seong Hoon ^{[3
]}

Kang, Ung Gu ^{[4
]}

Ahn, Yong Min ^{[4
]}

Kim, Yong Sik ^{[1
]}

机构：

[1] Dongguk Univ, Sch Med, Dongguk Univ Int Hosp, Dept Neuropsychiat, 27 Dongguk Ro, Goyang 10326, South Korea

[2] Seoul Natl Univ Hosp, Biomed Res Inst, Seoul, South Korea

[3] Eulji Univ, Eulji Univ Hosp, Sch Med, Dept Psychiat, Daejeon, South Korea

[4] Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea

来源：

PSYCHIATRY INVESTIGATION | 2018年 / 15卷 / 07期

关键词：

Electroconvulsive therapy; Circadian rhythm; Clock genes; Cortex; MAJOR DEPRESSIVE DISORDER; GLYCOGEN-SYNTHASE KINASE-3-BETA; CORE BODY-TEMPERATURE; MOOD DISORDERS; SUPRACHIASMATIC NUCLEUS; PREFRONTAL CORTEX; LIGHT THERAPY; RHYTHM DISTURBANCES; CLOCK PROTEIN; MOUSE-BRAIN;

D O I：

10.30773/pi.2018.01.18.2

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective Electroconvulsive therapy (ECT) is the most effective treatment for mood disorders. Accumulating evidence has suggested the important role of circadian genes in mood disorders. However, the effects of ECT on circadian genes have not been systemically investigated. Methods We examined the expression and daily oscillation of major circadian genes in the rat frontal cortex after electroconvulsive seizure (ECS). Results Firstly, mRNA and protein level were investigated at 24 hr after single ECS (E1X) and repeated ECS treatements for 10 days (E10X), which showed more remarkable changes after E10X than E1X. mRNA expression of Rora, Bmal1, Clock, Per1, and Cry1 was decreased, while Rev-erba expression was increased at 24 hr after E10X compared to sham. The proteins showed similar pattern of changes. Next, the effects on oscillation and rhythm properties (mesor, amplitude, and acrophase) were examined, which also showed more prominent changes after E10X than E1X. After E10X, mesor of Rora, Bmal1, and Cry1 was reduced, and that of Rev-erba was increased. Five genes, Rev-erba, Bmal1, Per1, Per2, and Cry2, showed earlier acrophase after E10X. Conclusion The findings suggest that repeated ECS induces reduced expression and phase advance of major circadian genes in the in vivo rat frontal cortex.

引用

页码：717 / 726

页数：10

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