Salinosporamide A:: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora

被引：821

作者：

Feling, RH ^{[1
]}

Buchanan, GO ^{[1
]}

Mincer, TJ ^{[1
]}

Kauffman, CA ^{[1
]}

Jensen, PR ^{[1
]}

Fenical, W ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 03期

关键词：

D O I：

10.1002/anie.200390115

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Strong and selective cytotoxicity toward a variety of cancer cell lines is shown by salinosporamide A (1), which was isolated from the culture extract of a unique marine actinomycete belonging to the recently discovered genus Salinospora.

引用

页码：355 / +

页数：4

共 10 条

[1] Search and discovery strategies for biotechnology: The paradigm shift [J].

Bull, AT ;

Ward, AC ;

Goodfellow, M .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2000, 64 (03) :573-+

[2]

Corey EJ, 1999, CHEM PHARM BULL, V47, P1

[3] The structural requirements for inhibition of proteasome function by the lactacystin-derived β-lactone and synthetic analogs [J].

Corey, EJ ;

Li, WDZ ;

Nagamitsu, T ;

Fenteany, G .

TETRAHEDRON, 1999, 55 (11) :3305-3316

[4] Mechanistic studies on the inactivation of the proteasome by lactacystin A central role for clasto-lactacystin beta-lactone [J].

Dick, LR ;

Cruikshank, AA ;

Grenier, L ;

Melandri, FD ;

Nunes, SL ;

Stein, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (13) :7273-7276

[5] Lactacystin, proteasome function, and cell fate [J].

Fenteany, G ;

Schreiber, SL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (15) :8545-8548

[6] Widespread and persistent populations of a major new marine actinomycete taxon in ocean sediments [J].

Mincer, TJ ;

Jensen, PR ;

Kauffman, CA ;

Fenical, W .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2002, 68 (10) :5005-5011

[7]

Okami Y., 1988, ACTINOMYCETES BIOTEC, P33, DOI DOI 10.1016/B978-0-12-289673-6.50007-5

[8] STRUCTURE OF LACTACYSTIN, A NEW MICROBIAL METABOLITE WHICH INDUCES DIFFERENTIATION OF NEUROBLASTOMA-CELLS [J].

OMURA, S ;

MATSUZAKI, K ;

FUJIMOTO, T ;

KOSUGE, K ;

FURUYA, T ;

FUJITA, S ;

NAKAGAWA, A .

JOURNAL OF ANTIBIOTICS, 1991, 44 (01) :117-118

[9] LACTACYSTIN, A NOVEL MICROBIAL METABOLITE, INDUCES NEURITOGENESIS OF NEUROBLASTOMA-CELLS [J].

OMURA, S ;

FUJIMOTO, T ;

OTOGURO, K ;

MATSUZAKI, K ;

MORIGUCHI, R ;

TANAKA, H ;

SASAKI, Y .

JOURNAL OF ANTIBIOTICS, 1991, 44 (01) :113-116

[10] Lactacystin, a proteasome inhibitor:: Discovery and its application in cell biology [J].

Tomoda, H ;

Ömura, S .

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2000, 120 (10) :935-949

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