Salinosporamide A:: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora

被引：811

作者：

Feling, RH ^{[1
]}

Buchanan, GO ^{[1
]}

Mincer, TJ ^{[1
]}

Kauffman, CA ^{[1
]}

Jensen, PR ^{[1
]}

Fenical, W ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 03期

关键词：

D O I：

10.1002/anie.200390115

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Strong and selective cytotoxicity toward a variety of cancer cell lines is shown by salinosporamide A (1), which was isolated from the culture extract of a unique marine actinomycete belonging to the recently discovered genus Salinospora.

引用

页码：355 / +

页数：4

共 10 条

[1] Search and discovery strategies for biotechnology: The paradigm shift
Bull, AT
Ward, AC
Goodfellow, M
[J]. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2000, 64 (03) : 573 - +
[2] Corey EJ, 1999, CHEM PHARM BULL, V47, P1
[3] The structural requirements for inhibition of proteasome function by the lactacystin-derived β-lactone and synthetic analogs
Corey, EJ
Li, WDZ
Nagamitsu, T
Fenteany, G
[J]. TETRAHEDRON, 1999, 55 (11) : 3305 - 3316
[4] Mechanistic studies on the inactivation of the proteasome by lactacystin A central role for clasto-lactacystin beta-lactone
Dick, LR
Cruikshank, AA
Grenier, L
Melandri, FD
Nunes, SL
Stein, RL
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (13) : 7273 - 7276
[5] Lactacystin, proteasome function, and cell fate
Fenteany, G
Schreiber, SL
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (15) : 8545 - 8548
[6] Widespread and persistent populations of a major new marine actinomycete taxon in ocean sediments
Mincer, TJ
Jensen, PR
Kauffman, CA
Fenical, W
[J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2002, 68 (10) : 5005 - 5011
[7] Okami Y., 1988, ACTINOMYCETES BIOTEC, P33, DOI DOI 10.1016/B978-0-12-289673-6.50007-5
[8] STRUCTURE OF LACTACYSTIN, A NEW MICROBIAL METABOLITE WHICH INDUCES DIFFERENTIATION OF NEUROBLASTOMA-CELLS
OMURA, S
MATSUZAKI, K
FUJIMOTO, T
KOSUGE, K
FURUYA, T
FUJITA, S
NAKAGAWA, A
[J]. JOURNAL OF ANTIBIOTICS, 1991, 44 (01) : 117 - 118
[9] LACTACYSTIN, A NOVEL MICROBIAL METABOLITE, INDUCES NEURITOGENESIS OF NEUROBLASTOMA-CELLS
OMURA, S
FUJIMOTO, T
OTOGURO, K
MATSUZAKI, K
MORIGUCHI, R
TANAKA, H
SASAKI, Y
[J]. JOURNAL OF ANTIBIOTICS, 1991, 44 (01) : 113 - 116
[10] Lactacystin, a proteasome inhibitor:: Discovery and its application in cell biology
Tomoda, H
Ömura, S
[J]. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2000, 120 (10): : 935 - 949

← 1 →