Life Cycle of Cryptococcus neoformans

被引：75
作者：
Zhao, Youbao [1 ]
Lin, Jianfeng [1 ]
Fan, Yumeng [1 ]
Lin, Xiaorong [1 ]
机构：
[1] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA
来源：
ANNUAL REVIEW OF MICROBIOLOGY, VOL 73 | 2019年 / 73卷
基金：
美国国家卫生研究院;
关键词：
life cycle; sexual reproduction; mating; dimorphism; morphogenesis; pathogenesis; MAP KINASE CASCADE; MATING-TYPE; SEXUAL DEVELOPMENT; FILOBASIDIELLA-NEOFORMANS; USTILAGO-MAYDIS; VAR; GRUBII; SACCHAROMYCES-CEREVISIAE; UNISEXUAL REPRODUCTION; HOMEODOMAIN PROTEINS; CATALYTIC SUBUNITS;
D O I：
10.1146/annurev-micro-020518-120210
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cryptococcus neoformans is a ubiquitous environmental fungus and an opportunistic pathogen that causes fatal cryptococcal meningitis. Advances in genomics, genetics, and cellular and molecular biology of C. neoformans have dramatically improved our understanding of this important pathogen, rendering it a model organism to study eukaryotic biology and microbial pathogenesis. In light of recent progress, we describe in this review the life cycle of C. neoformans with a special emphasis on the regulation of the yeast-to-hypha transition and different modes of sexual reproduction, in addition to the impacts of the life cycle on cryptococcal populations and pathogenesis.
引用
收藏
页码：17 / 42
页数：26
相关论文
共 191 条
[51]   IMMUNIZATION OF MICE WITH AN AVIRULENT PSEUDO-HYPHAL FORM OF CRYPTOCOCCUS NEOFORMANS [J].
FROMTLING, RA ;
BLACKSTOCK, R ;
HALL, NK ;
BULMER, GS .
MYCOPATHOLOGIA, 1979, 68 (03) :179-181
[52]   Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in Cryptococcus deneoformans [J].
Fu, Ci ;
Donadio, Nicholas ;
Cardenas, Maria E. ;
Heitman, Joseph .
GENETICS, 2018, 208 (02) :639-653
[53]   PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex [J].
Fu, Ci ;
Heitman, Joseph .
PLOS GENETICS, 2017, 13 (11)
[54]   Insertional mutagenesis combined with an inducible filamentation phenotype reveals a conserved STE50 homologue in Cryptococcus neoformans that is required for monokaryotic fruiting and sexual reproduction [J].
Fu, J. ;
Mares, C. ;
Lizcano, A. ;
Liu, Y. ;
Wickes, B. L. .
MOLECULAR MICROBIOLOGY, 2011, 79 (04) :990-1007
[55]   Dimorphism in Fungal Pathogens of Mammals, Plants, and Insects [J].
Gauthier, Gregory M. .
PLOS PATHOGENS, 2015, 11 (02)
[56]   Polyploid Titan Cells Produce Haploid and Aneuploid Progeny To Promote Stress Adaptation [J].
Gerstein, Aleeza C. ;
Fu, Man Shun ;
Mukaremera, Liliane ;
Li, Zhongming ;
Ormerod, Kate L. ;
Fraser, James A. ;
Berman, Judith ;
Nielsen, Kirsten .
MBIO, 2015, 6 (05)
[57]   Elucidating the Pathogenesis of Spores from the Human Fungal Pathogen Cryptococcus neoformans [J].
Giles, Steven S. ;
Dagenais, Taylor R. T. ;
Botts, Michael R. ;
Keller, Nancy P. ;
Hull, Christina M. .
INFECTION AND IMMUNITY, 2009, 77 (08) :3491-3500
[58]   Pheromone independent unisexual development in Cryptococcus neoformans [J].
Gyawali, Rachana ;
Zhao, Youbao ;
Lin, Jianfeng ;
Fan, Yumeng ;
Xu, Xinping ;
Upadhyay, Srijana ;
Lin, Xiaorong .
PLOS GENETICS, 2017, 13 (05)
[59]   A Family of Secretory Proteins Is Associated with Different Morphotypes in Cryptococcus neoformans [J].
Gyawali, Rachana ;
Upadhyay, Srijana ;
Way, Joshua ;
Lin, Xiaorong .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2017, 83 (05)
[60]   Prezygotic and Postzygotic Control of Uniparental Mitochondrial DNA Inheritance in Cryptococcus neoformans [J].
Gyawali, Rachana ;
Lin, Xiaorong .
MBIO, 2013, 4 (02)
12345678910