Life Cycle of Cryptococcus neoformans

被引：75
作者：
Zhao, Youbao [1 ]
Lin, Jianfeng [1 ]
Fan, Yumeng [1 ]
Lin, Xiaorong [1 ]
机构：
[1] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA
来源：
ANNUAL REVIEW OF MICROBIOLOGY, VOL 73 | 2019年 / 73卷
基金：
美国国家卫生研究院;
关键词：
life cycle; sexual reproduction; mating; dimorphism; morphogenesis; pathogenesis; MAP KINASE CASCADE; MATING-TYPE; SEXUAL DEVELOPMENT; FILOBASIDIELLA-NEOFORMANS; USTILAGO-MAYDIS; VAR; GRUBII; SACCHAROMYCES-CEREVISIAE; UNISEXUAL REPRODUCTION; HOMEODOMAIN PROTEINS; CATALYTIC SUBUNITS;
D O I：
10.1146/annurev-micro-020518-120210
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cryptococcus neoformans is a ubiquitous environmental fungus and an opportunistic pathogen that causes fatal cryptococcal meningitis. Advances in genomics, genetics, and cellular and molecular biology of C. neoformans have dramatically improved our understanding of this important pathogen, rendering it a model organism to study eukaryotic biology and microbial pathogenesis. In light of recent progress, we describe in this review the life cycle of C. neoformans with a special emphasis on the regulation of the yeast-to-hypha transition and different modes of sexual reproduction, in addition to the impacts of the life cycle on cryptococcal populations and pathogenesis.
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页码：17 / 42
页数：26
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