Quantitative CARS Microscopic Detection of Analytes and Their Isotopomers in a Two-Channel Microfluidic Chip

被引:36
作者
Bergner, Gero [1 ,3 ]
Chatzipapadopoulos, Susana [3 ]
Akimov, Denis [3 ]
Dietzek, Benjamin [3 ,4 ]
Malsch, Daniell [3 ]
Henkel, Thomas [3 ]
Schluecker, Sebastian [1 ,2 ]
Popp, Juergen [3 ,4 ]
机构
[1] Univ Wurzburg, Inst Phys Chem, D-97074 Wurzburg, Germany
[2] Univ Osnabruck, Dept Phys, D-49069 Osnabruck, Germany
[3] Inst Photon Technol, D-07745 Jena, Germany
[4] Univ Jena, Inst Phys Chem, D-07743 Jena, Germany
关键词
analytical methods; CARS microscopy; isotopomers microfluidics; Raman spectroscopy; RAMAN; MICROSPECTROSCOPY;
D O I
10.1002/smll.200900807
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Fast and quantitative detection of organic analytes is achieved by coherent anti-Stokes Raman scattering (CARS) microscopy using a two-channel microfluidic chip in combination with deuterated isotopomers as a reference (see picture). This experimental design enables the simultaneous measurement of both the chemically relevant Raman-resonant signal and the non-Raman-resonant background.
引用
收藏
页码:2816 / 2818
页数:3
相关论文
共 17 条
[1]   Quantitative online detection of low-concentrated drugs via a SERS microfluidic system [J].
Ackermann, Katrin R. ;
Henkel, Thomas ;
Popp, Juergen .
CHEMPHYSCHEM, 2007, 8 (18) :2665-2670
[2]   Different contrast information obtained from CARS and nonresonant FWM images [J].
Akimov, Denis ;
Chatzipapadopoulos, Susana ;
Meyer, Tobias ;
Tarcea, Nicolae ;
Dietzek, Benjamin ;
Schmitt, Michael ;
Popp, Juergen .
JOURNAL OF RAMAN SPECTROSCOPY, 2009, 40 (08) :941-947
[3]   Dual-pump coherent anti-Stokes-Raman scattering microscopy [J].
Burkacky, Ondrej ;
Zumbusch, Andreas ;
Brackmann, Christian ;
Enejder, Annika .
OPTICS LETTERS, 2006, 31 (24) :3656-3658
[4]   Multiplex coherent anti-stokes Raman scattering microspectroscopy and study of lipid vesicles [J].
Cheng, JX ;
Volkmer, A ;
Book, LD ;
Xie, XS .
JOURNAL OF PHYSICAL CHEMISTRY B, 2002, 106 (34) :8493-8498
[5]   Raman and CARS microspectroscopy of cells and tissues [J].
Krafft, Christoph ;
Dietzek, Benjamin ;
Popp, Juergen .
ANALYST, 2009, 134 (06) :1046-1057
[6]   A comparative Raman and CARS imaging study of colon tissue [J].
Krafft, Christoph ;
Ramoji, Anuradha A. ;
Bielecki, Christiane ;
Vogler, Nadine ;
Meyer, Tobias ;
Akimov, Denis ;
Roesch, Petra ;
Schmitt, Michael ;
Dietzek, Benjamin ;
Petersen, Iver ;
Stallmach, Andreas ;
Popp, Juergen .
JOURNAL OF BIOPHOTONICS, 2009, 2 (05) :303-312
[7]  
Lakowicz J.R., 2006, PRINCIPLES FLUORESCE, V3rd, DOI DOI 10.1007/978-0-387-46312-4
[8]   Three-dimensional molecular mapping of a multiple emulsion by means of CARS microscopy [J].
Meyer, Tobias ;
Akimov, Denis ;
Tarcea, Nicolae ;
Chatzipapadopoulos, Susana ;
Muschiolik, Gerald ;
Kobow, Jens ;
Schmitt, Michael ;
Popp, Juergen .
JOURNAL OF PHYSICAL CHEMISTRY B, 2008, 112 (05) :1420-1426
[9]   Triple-Resonance Coherent Anti-Stokes Raman Scattering Microspectroscopy [J].
Min, Wei ;
Lu, Sijia ;
Holtom, Gary R. ;
Xie, X. Sunney .
CHEMPHYSCHEM, 2009, 10 (02) :344-347
[10]   Coherent anti-stokes Raman scattering microscopy [J].
Muller, Michiel ;
Zumbusch, Andreas .
CHEMPHYSCHEM, 2007, 8 (15) :2156-2170