A New Sesquiterpenoid from Chrysanthemum indicum

被引：8

作者：

Chen, Jia ^{[1
,2
]}

Yang, Xu ^{[3
]}

Li, Bo ^{[4
,5
]}

Yang, Kun ^{[3
]}

Wang, Yiqin ^{[2
]}

Sun, Kexing ^{[1
]}

Zhang, Yong ^{[4
,5
]}

Zhu, Weiliang ^{[4
,5
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Shanghai 200127, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China

[3] Chengdu Univ Tradit Chinese Med, Chengdu 611137, Sichuan, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China

[5] Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2019年 / 55卷 / 06期

基金：

中国博士后科学基金;

关键词：

Chrysanthemum indicum; sesquiterpenoid; glucoside; nitric oxide production; CHEMICAL-CONSTITUENTS; FLOWERS; GLYCOSIDES;

D O I：

10.1007/s10600-019-02898-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel glucoside sesquiterpenoid (1) was isolated from Chrysanthemum indicum L. flowers, together with 14 known compounds (2-15), among which eight compounds (3, 4, 8, and 10-14) were isolated from the plant for the first time. Their structures were determined on the basis of the interpretation of spectroscopic data, viz., ESI-MS, HR-TOF-MS, IR, and NMR. The effects of these compounds onlipopolysaccharide-induced nitric oxide production by RAW 264.7 cells were investigated. Compounds 2, 3, and 7 showed strong or moderate inhibitory effects at 100 mu M, and the IC50 values of 3 and 7 were 36.09 and 9.59 mu M, respectively.

引用

页码：1076 / 1079

页数：4

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