The role of T cells in the microenvironment of Hodgkin lymphoma

被引：45
作者：
Wein, Frederik [1 ]
Kueppers, Ralf [1 ]
机构：
[1] Univ Duisburg Essen, Fac Med, Inst Cell Biol Canc Res, D-45122 Essen, Germany
来源：
JOURNAL OF LEUKOCYTE BIOLOGY | 2016年 / 99卷 / 01期
关键词：
hematology; chemokines; immune evasion; REED-STERNBERG CELLS; EPSTEIN-BARR-VIRUS; FOSTERS IMMUNE PRIVILEGE; FUNCTIONAL CD30 LIGAND; GENE-EXPRESSION; B-CELLS; INFILTRATING LYMPHOCYTES; FLOW-CYTOMETRY; MAST-CELLS; DISEASE;
D O I：
10.1189/jlb.3MR0315-136R
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The cellular microenvironment in HL is dominated by amixed infiltrate of inflammatory cells with typically only 1 or a few percent of HRS tumor cells. HRS cells orchestrate this infiltrate by the secretion of a multitude of chemokines. T cells are usually the largest population of cells in the HL tissue, encompassing Th cells, T-regs, and CTLs. Th cells and Tregs presumably provide essential survival signals for the HRS cells, and the Tregs also play an important role in rescuing HRS cells from an attack by CTLs and NK cells. The interference with this complex interplay of HRS cells with other immune cells in the microenvironment may provide novel strategies for targeted immunotherapies.
引用
收藏
页码：45 / 50
页数：6
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