Epidemiology and Comorbidities of Psoriasis among Israeli Adolescents: A Large Cross-Sectional Study

被引:13
作者
Shreberk-Hassidim, Rony [1 ]
Galili, Eran [2 ,3 ]
Hassidim, Ayal [4 ]
Ramot, Yuval [1 ]
Merdler, Ilan [5 ]
Baum, Sharon [2 ,3 ]
Zlotogorski, Abraham [1 ]
Barzilai, Aviv [2 ,3 ]
Astman, Nadav [2 ,3 ,6 ]
机构
[1] Hebrew Univ Jerusalem, Fac Med, Hadassah Med Ctr, Dept Dermatol, Jerusalem, Israel
[2] Chaim Sheba Med Ctr, Dept Dermatol, Tel Hashomer, Israel
[3] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
[4] Hebrew Univ Jerusalem, Fac Med, Hadassah Med Ctr, Dept Plast Surg, Jerusalem, Israel
[5] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Internal Med H, Tel Aviv, Israel
[6] Israel Def Forces, Med Corps, Tel Hashomer, Israel
关键词
Adolescents; Body mass index; Epidemiology; Obesity; Psoriasis; QUALITY-OF-LIFE; PEDIATRIC PSORIASIS; CHILDREN; MULTICENTER; SEVERITY; EXCESS;
D O I
10.1159/000501032
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background and Aims: Although psoriasis can develop at any age, the data regarding its characteristics in adolescents are sparse. This study was designed to determine the psoriasis prevalence and its associations with the body mass index (BMI), lipid profile, and comorbidities in adolescents. Methods: This was a nationwide population-based cross-sectional retrospective study of adolescents (16-18 years old) evaluated for military service between January 1999 and January 2014. Results: Our database included 887,765 adolescents (57.1% males), of whom 3,112 (0.35%) were diagnosed with psoriasis. During the 15-year study period, the psoriasis prevalence increased by 1.4-fold, from 0.3 to 0.42% (1.25-fold for the males and 1.63-fold for the females). Certain comorbidities, such as contact dermatitis, hyperhidrosis, and arthritis, were significantly associated with psoriasis (odds ratios [ORs] of 2.26, 1.51, and 5.3, respectively). The adolescents with psoriasis had significantly elevated BMI and triglyceride values. We found increased ORs of 1.34 (95% confidence interval [CI] = 1.25-1.56) and 1.56 (95% CI = 1.32-1.83) for the overweight and obese adolescents, respectively, while a lower BMI (<20) had an opposite effect with psoriasis (OR = 0.8). Conclusions: Based on our results, the psoriasis prevalence in Israeli adolescents is rising. Dermatological comorbidities and an increased BMI were associated with psoriasis in these adolescents. A better understanding of the distinctive epidemiological characteristics of juvenile psoriasis may allow for the early detection of comorbidities and improve its management.
引用
收藏
页码:488 / 494
页数:7
相关论文
共 28 条
  • [1] Epidemiology and comorbidity of psoriasis in children
    Augustin, M.
    Glaeske, G.
    Radtke, M. A.
    Christophers, E.
    Reich, K.
    Schaefer, I.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2010, 162 (03) : 633 - 636
  • [2] Excess Adiposity Preceding Pediatric Psoriasis
    Becker, Lauren
    Tom, Wynnis L.
    Eshagh, Karin
    Benjamin, Latanya T.
    Paller, Amy S.
    [J]. JAMA DERMATOLOGY, 2014, 150 (05) : 573 - 574
  • [3] Psychiatric Symptoms and Health-Related Quality of Life in Children and Adolescents with Psoriasis
    Bilgic, Ayhan
    Bilgic, Ozlem
    Akis, Havva Kaya
    Eskioglu, Fatma
    Kilic, Emine Zinnur
    [J]. PEDIATRIC DERMATOLOGY, 2010, 27 (06) : 614 - 617
  • [4] Psoriasis in Children and Adolescents: Diagnosis, Management and Comorbidities
    Bronckers, I. M. G. J.
    Paller, A. S.
    van Geel, M. J.
    van de Kerkhof, P. C. M.
    Seyger, M. M. B.
    [J]. PEDIATRIC DRUGS, 2015, 17 (05) : 373 - 384
  • [5] The epidemiology of childhood psoriasis: a scoping review
    Burden-Teh, E.
    Thomas, K. S.
    Ratib, S.
    Grindlay, D.
    Adaji, E.
    Murphy, R.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2016, 174 (06) : 1242 - 1257
  • [6] Juvenile psoriasis in European and Asian children: similarities and differences
    Chiam, L. Y. T.
    de Jager, M. E. A.
    Giam, Y. C.
    de Jong, E. M. G. J.
    van de Kerkhof, P. C. M.
    Seyger, M. M. B.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2011, 164 (05) : 1101 - 1103
  • [7] NATURAL-HISTORY OF PSORIASIS IN 5,600 PATIENTS
    FARBER, EM
    NALL, ML
    [J]. DERMATOLOGICA, 1974, 148 (01): : 1 - 18
  • [8] Sex-specific associations between adolescent categories of BMI with cardiovascular and non-cardiovascular mortality in midlife
    Furer, Ariel
    Afek, Arnon
    Orr, Omri
    Gershovitz, Liron
    Rabbi, Moran Landau
    Derazne, Estela
    Pinhas-Hamiel, Orit
    Fink, Noam
    Leiba, Adi
    Tirosh, Amir
    Kark, Jeremy D.
    Twig, Gilad
    [J]. CARDIOVASCULAR DIABETOLOGY, 2018, 17
  • [9] Neuropsychiatric comorbidity among adolescents with psoriasis
    Galili, E.
    Barzilai, A.
    Shreberk-Hassidim, R.
    Merdler, I.
    Caspi, T.
    Astman, N.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2018, 178 (04) : 910 - 916
  • [10] Prevalence and treatment of psoriasis in the United Kingdom - A population-based study
    Gelfand, JM
    Weinstein, R
    Porter, SB
    Neimann, AL
    Berlin, JA
    Margolis, D
    [J]. ARCHIVES OF DERMATOLOGY, 2005, 141 (12) : 1537 - 1541