A convenient and efficient synthesis of sialyl Lewis X

被引：3
作者：
Baba, K
Iwata, N
Hamajima, H
Ikami, T
Ishida, H
Hasegawa, A
Kiso, M
机构：
[1] Sanwa Kagaku Kenkyusho Co Ltd, Drug Discovery Res Lab, Hokusei, Mie 51104, Japan
[2] Gifu Univ, Dept Appl Bioorgan Chem, Gifu 50111, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1998年 / 62卷 / 03期
关键词：
selectin; glycosylation; sialyl Lewis X;
D O I：
10.1271/bbb.62.590
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
a convenient synthesis of the sialyl Lewis X (sLe(x)) tetrasaccharide, NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNac (8), as a carbohydrate ligand for selectins is described. The key step is the reaction between NeuAc alpha 2-3GalSMe (5) as a glycosyl donor and the suitably protected Fuc alpha 1-3GlcNac derivative (4) as the glycosyl acceptor by using dimethyl(methylthio)sulfonium triflate (DMTST) as the promoter.
引用
收藏
页码：590 / 592
页数：3
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