Analgesic, anti-inflammatory and immuno-modulatory effects of dezocine-propofol anesthesia combination following colonoscopy

Purpose: To study and compare the analgesic, anti-inflammatory and immuno-modulatory effects of dezocine-propofol, and fentanyl-propofol combinations in colonoscopy. Methods: One hundred and thirty-four patients who received painless colonoscopy in Eastern Medical District of Linyi People's Hospital, Linyi City, Shandong Province, China, from June 2013 to December 2016 were randomly divided into two groups. Patients in the observation group (aged 42 - 65 years) received dezocine-propofol combination as anesthesia, while those in the control group (aged 41 - 67 years) were anesthetized with fentanyl-propofol. Serum levels of pain and inflammatory mediators, as well as contents of immune response molecules were determined prior to, during and after colonoscopy using either enzyme-linked immunosorbent assay (ELISA) or electro-chemiluminescence kits. Results: There were no statistically significant differences in the serum levels of 5-hydroxytryptophan (5-HTP), 5-hydroxy indole acetic acid (5-HIAA), substance P (SP), prostaglandin E2 (PGE2), C-reactive protein (CRP), heat shock protein 70 (HSP70), Interleukin-1 beta(IL-1 beta), adrenocorticotropic hormone (ACTH), Cortisol (Cor), Inositol (Ins), c-peptide (C-P), immunoglobulin G (IgG) and immunoglobulin A (IgA), complement 3 (C3) and complement 4 (C4) before and during colonoscopy between the two groups of patients. However, after the examination, serum levels of 5-HTP, 5-HIAA, SP, PGE2, CRP, HSP70, IL-1 beta, ACTH, Cor, Ins and C-P in the observation group were significantly lower than those in control group (p < 0.05), while IgG, IgA, C3 and C4 contents were significantly higher than those of the control group (p < 0.05). Conclusion: These results suggest that the analgesic effect of dezocine-propofol combination after colonoscopy examination is superior to that of fentanyl-propofol combination, due to its effectiveness in inhibiting inflammatory reactions and improving immune response.