Efficacy of albaconazole (UR-9825) in treatment of disseminated Scedosporium prolificans infection in rabbits

被引：44

作者：

Capilla, J

Yustes, C

Mayayo, E

Fernández, B

Ortoneda, M

Pastor, FJ

Guarro, J

机构：

[1] Univ Rovira & Virgili, Fac Med, Unitat Microbiol, E-43201 Reus, Spain

[2] Univ Rovira & Virgili, Fac Med, Unitat Anat Patol, E-43201 Reus, Spain

[3] Hosp Univ Terragona Joan XXIII, Serv Patol, Tarragona, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 06期

关键词：

D O I：

10.1128/AAC.47.6.1948-1951.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

There are no effective therapeutics for treating invasive Scedosporium prolificans infections. Doses of 15, 25, and 50 mg/kg of body weight/day for the new triazole albaconazole (ABC) were evaluated in an immunocompetent rabbit model of systemic infection with this mold. Treatments were begun 1 day after challenge and given for 10 days. ABC at any dose was more effective than amphotericin B (AMB) at 0.8 mg/kg/day at clearing S. prolificans from tissue (P < 0.007). The percentages of survival at 25 mg of ABC/kg/day were similar to those obtained with AMB. Rabbits showed 100% survival when they were treated with 50 mg of ABC per kg (P < 0.0001 versus control group), and only this dosage was able to reduce tissue burden significantly in the five organs studied, i.e., spleen, kidneys, liver, lungs, and brain.

引用

页码：1948 / 1951

页数：4

共 23 条

[21] Efficacies of two new antifungal agents, the triazole ravuconazole and the echinocandin LY-303366, in an experimental model of invasive aspergillosis [J].