Functional genomics of lactic acid bacteria: from food to health

被引：121

作者：

Douillard, Franois P. ^{[1
]}

de Vos, Willem M. ^{[1
,2
,3
]}

机构：

[1] Univ Helsinki, Dept Vet Biosci, Helsinki 00790, Finland

[2] Wageningen Univ, Microbiol Lab, NL-6703 HB Wageningen, Netherlands

[3] Univ Helsinki, Dept Bacteriol & Immunol, FIN-00014 Helsinki, Finland

来源：

MICROBIAL CELL FACTORIES | 2014年 / 13卷

基金：

芬兰科学院; 欧洲研究理事会;

关键词：

SORTASE-DEPENDENT PROTEINS; LACTOBACILLUS-RHAMNOSUS GG; JOHNSONII STRAIN NCC533; LACTOCOCCUS-LACTIS; IN-VITRO; GASTROINTESTINAL-TRACT; VAGINAL LACTOBACILLI; GENE-EXPRESSION; STREPTOCOCCUS-THERMOPHILUS; TRANSCRIPTIONAL RESPONSE;

D O I：

10.1186/1475-2859-13-S1-S8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Genome analysis using next generation sequencing technologies has revolutionized the characterization of lactic acid bacteria and complete genomes of all major groups are now available. Comparative genomics has provided new insights into the natural and laboratory evolution of lactic acid bacteria and their environmental interactions. Moreover, functional genomics approaches have been used to understand the response of lactic acid bacteria to their environment. The results have been instrumental in understanding the adaptation of lactic acid bacteria in artisanal and industrial food fermentations as well as their interactions with the human host. Collectively, this has led to a detailed analysis of genes involved in colonization, persistence, interaction and signaling towards to the human host and its health. Finally, massive parallel genome re-sequencing has provided new opportunities in applied genomics, specifically in the characterization of novel non-GMO strains that have potential to be used in the food industry. Here, we provide an overview of the state of the art of these functional genomics approaches and their impact in understanding, applying and designing lactic acid bacteria for food and health.

引用

页数：21

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