Isolation, purification, structural characteristics, pharmacological activities, and combined action of Hedyotis diffusa polysaccharides: A review

被引：36
|
作者：
Zhang, Rui [1 ]
Ma, Chuanjiang [2 ]
Wei, Yongli [2 ]
Wang, Xin [2 ]
Jia, Jing [2 ]
Li, Ji [2 ]
Li, Kunlun [3 ]
Cao, Guangshang [4 ]
Yang, Peimin [4 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Sch Pharm, Jinan 250355, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Grade Lab Tradit Chinese Med Preparat 3, Natl Adm Tradit Chinese Med, Affiliated Hosp, Jinan 250014, Peoples R China
[3] Jinan Hangchen Biotechnol Co Ltd, Jinan 250014, Peoples R China
[4] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Jinan 250014, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2021年 / 183卷
基金：
中国国家自然科学基金;
关键词：
Hedyotis diffusa polysaccharides; Isolation; Purification; Pharmacological activity; Combined action; ANTIOXIDANT; CELLS; BIOACTIVITIES; INHIBITION; INVASION;
D O I：
10.1016/j.ijbiomac.2021.04.139
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hedyotis diffusa polysaccharides, as the main component and an important bioactive substance of Hedyotis diffusa , are effective immunomodulators with various pharmacological activities, including antitumour, anti-inflammatory, antioxidant, anti-fatigue and immunity-enhancing activities. The total polysaccharides extracted from Hedyotis diffusa and Scutellaria barbata have great effects in treating liver cancer, gastric cancer, rectal cancer, glioma and nasopharyngeal carcinoma. Moreover, different materials and extraction methods result in differences in the structure and bioactivity of Hedyotis diffusa polysaccharides. Therefore, this paper summarizes the isolation, purification, structural characteristics, pharmacological activities, and combined action of Hedyotis diffusa polysaccharides to provide a reference for further study. (C) 2021 Elsevier B.V. All rights reserved.
引用
收藏
页码：119 / 131
页数：13
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