MK-801 upregulates the expression of D-amino acid oxidase mRNA in rat brain

被引：22
作者：
Yoshikawa, M
Oka, T
Kawaguchi, M
Hashimoto, A [1 ]
机构：
[1] Tokai Univ, Sch Med, Dept Pharmacol, Isehara, Kanagawa 2591143, Japan
[2] Tokyo Dent Coll, Dept Pharmacol, Mihama Ku, Chiba 2618502, Japan
来源：
MOLECULAR BRAIN RESEARCH | 2004年 / 131卷 / 1-2期
关键词：
D-Amino acid oxidase; N-methyl-D-aspartate receptor; real-time quantitative PCR; schizophrenia; D-serine; serine racemase;
D O I：
10.1016/j.molbrainres.2004.08.017
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We have evaluated the effect of the systemic administration of MK-801 (0.4 mg/kg) on the gene expression of D-amino acid oxidase (DAO) in several brain areas of the rat. The levels of DAO mRNA in all the brain areas significantly increased and peaked at 4 h after the administration. The present results suggest that there is a link between the expression of DAO mRNA and the N-methyl-D-aspartate (NMDA) receptor activity. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：141 / 144
页数：4
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