Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2

被引：9

作者：

Yang, Yalong ^{[1
,2
]}

Xu, Fenghua ^{[1
]}

机构：

[1] Peoples Liberat Army PLA Gen Hosp, Med Supplies Ctr, Dept Pharm, Pharmaceut Sci Res Div, Beijing, Peoples R China

[2] Med Sch Chinese, Peoples Liberat Army PLA, Beijing, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

SARS-CoV-2; antibody-dependent enhancement (ADE); mechanism; receptor-mediated; multiple roles of macrophages; countermeasures; SARS-COV; CELLS;

D O I：

10.3389/fimmu.2022.1008285

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Since immune system and internal environment in vivo are large and complex, the interpretation of the observed immune effect from the perspective of a single immune cell or antibody seems a little feeble. Many studies have shown that specific antibodies against " former" viruses have a reduced ability to neutralize "new" mutant strains. However, there is no comprehensive and clear view of whether there will be Antibody-dependent enhancement (ADE). We review the latest relevant studies, hoping to explain the ADE of SARS-CoV-2 infection sometimes observed in some patients.

引用

页数：6

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